Results 201 to 210 of about 60,603 (249)

Establishment of Interspecies Somatic Cell Nuclear Transfer and Transgene‐Free Inducible Pluripotent Stem Cells for Versatile Conservation of the Germplasm Resource of Wild Boar

Animal Research and One Health, Volume 4, Issue 3, Page 347-351, August 2026.
Conserving genetic material and even increasing genetic diversity is critical. To conduct the conservation of wild boar germplasm resources, we have successfully obtained healthy cloned wild boars for the first time using interspecies somatic cell nuclear transfer and established transgene‐free iPSCs that can be used to conduct iterative rounds of gene
Chen Gao, Xinyi Zhou, Shigang Gu, Jianbo Li, Jing Wang, Yurong Zhang, Wenxuan Zhao, Xinhua Wei, Liting Lu, Quanmin Zhao, Yongye Huang, Dawei Yu   +11 more
wiley   +1 more source

Primordial germ cell DNA demethylation and development require DNA translesion synthesis. [PDF]

Nat Commun
Shah P, Hill R, Dion C, Clark SJ, Abakir A, Willems J, Arends MJ, Garaycoechea JI, Leitch HG, Reik W, Reik W, Crossan GP.   +11 more
europepmc   +1 more source

Epigenetic Mechanisms Underlying Cognitive Dysfunction in Parkinson's Disease: Current Evidence and Future Prospects

Brain and Behavior, Volume 16, Issue 8, August 2026.
Epigenetic mechanismsincluding DNA methylation, histone modifications, and microRNA (miRNA) regulationmodulate gene expression without altering the DNA sequence and are increasingly implicated in the cognitive impairment associated with Parkinson's disease (PD). Environmental and molecular factors influence these epigenetic pathways, leading to altered
Fatemeh Hasani, Mohammad Ebrahim Kherad, Mohammad Sharifi Sarasyabi, Kimia Jazi, Ali Ashkbari, Payam Ahmadi, Hadise Heidarpour, Mahdi Masrour, Sina Khamaki, Rahem Rahmati, Andrei Surguchov   +10 more
wiley   +1 more source

Divergent MYB paralogs determine spatial distribution of linalool mediated by JA and DNA demethylation participating in aroma formation and cold tolerance of tea plants. [PDF]

Plant Biotechnol J
Yue R, Li Y, Qi Y, Liang X, Zheng Z, Ye Z, Tong W, Si X, Zhang Y, Xia E, Li P.   +10 more
europepmc   +1 more source

Genome-wide characterization of dynamic DNA 5-hydroxymethylcytosine and TET2-related DNA demethylation during breast tumorigenesis. [PDF]

Clin Epigenetics
Wu SL, Yang L, Huang C, Li Q, Ma C, Yuan F, Zhou Y, Wang X, Tong WM, Niu Y, Jin F.   +10 more
europepmc   +1 more source

DNA demethylation in the hypothalamus promotes transcription of Agtr1a and Slc12a2 and hypertension development. [PDF]

J Biol Chem
Ghosh K, Zhou JJ, Shao JY, Chen SR, Pan HL.   +4 more
europepmc   +1 more source

Deficiency of T follicular helper cell Tet3 DNA demethylation inhibits pathogenic IgG2c class switching and chronic GVHD.

Blood
Zaiken MC, Jin S, McDonald-Hyman CS, Hartigan CR, Sage PT, Hippen KL, Koehn BH, Panoskaltsis-Mortari A, Riddle MJ, Eide CR, Tolar J, Hill GR, Luznik L, Cutler CS, Ritz JR, Kean LS, Tsagaratou A, Rao A, Blazar BR.   +18 more
europepmc   +1 more source

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Active DNA demethylation and DNA repair

Differentiation, 2009
DNA methylation on cytosine is an epigenetic modification and is essential for gene regulation and genome stability in vertebrates. Traditionally DNA methylation was considered as the most stable of all heritable epigenetic marks. However, it has become clear that DNA methylation is reversible by enzymatic "active" DNA demethylation, with examples in ...
Christof Niehrs
exaly   +3 more sources

DNA Methylation and Demethylation in Plant Immunity

Annual Review of Phytopathology, 2016
Detection of plant and animal pathogens triggers a massive transcriptional reprogramming, which is directed by chromatin-based processes, and ultimately results in antimicrobial immunity. Although the implication of histone modifications in orchestrating biotic stress–induced transcriptional reprogramming has been well characterized, very little was ...
Luis Navarro
exaly   +4 more sources

DNA Demethylation and Carcinogenesis

Biochemistry (Moscow), 2005
DNA methylation plays an important role in the establishment and maintenance of the program of gene expression. Tumor cells are characterized by a paradoxical alteration of DNA methylation pattern: global DNA demethylation and local hypermethylation of certain genes.
N P, Kisseljova, F L, Kisseljov
openaire   +2 more sources