Results 201 to 210 of about 60,468 (238)
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DNA demethylation increases NETosis
Archives of Biochemistry and Biophysics, 2020Neutrophil extracellular traps (NETs) occur during the development of autoimmune diseases, cancer and diabetes. A novel form of cell death that is induced by NETs is called NETosis. Although these diseases are known to have an epigenetic component, epigenetic regulation of NETosis has not previously been explored.
Hiroyuki Yasuda +5 more
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Gadd45 in DNA Demethylation and DNA Repair
2022Growth arrest and DNA damage 45 (Gadd45) family genes, Gadd45A, Gadd45B, and GADD45 G are implicated as stress sensors that are rapidly induced upon genotoxic/physiological stress. They are involved in regulation of various cellular functions such as DNA repair, senescence, and cell cycle control.
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Active DNA demethylation by Gadd45 and DNA repair
Trends in Cell Biology, 2012How DNA methylation patterns are established, maintained and remodeled is incompletely understood, however, it has become clear that DNA methylation is reversible and dynamic as a result of enzymatic DNA demethylation. Several different mechanisms that may account for demethylation have recently been put forward and all seem to involve DNA repair. Here,
Christof Niehrs, Andrea Schäfer
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2016
The regulation of the genome relies on the overlying epigenome to instruct, define, and restrict the activities of cellular differentiation and growth integral to embryonic development, as well as defining the key activities of terminally differentiated cell types.
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The regulation of the genome relies on the overlying epigenome to instruct, define, and restrict the activities of cellular differentiation and growth integral to embryonic development, as well as defining the key activities of terminally differentiated cell types.
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Involvement of MEM1 in DNA demethylation in Arabidopsis
Plant Molecular Biology, 2020MEM1 participates in ROS1-mediated DNA demethylation pathway, and acts functionally as ROS3 to counteract the effects of RdDM pathway.mem1mutation leads to large numbers of hyper-DMRs inArabidopsisgenome. In higher plants, DNA methylation performs important functions in silencing transcribed genes and transposable elements (TEs).
Yanke Lu +10 more
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Demystifying DNA Demethylation
Science, 2011DNA modifying and repair enzymes make a new connection in the mechanism of DNA demethylation.
Christopher S. Nabel, Rahul M. Kohli
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DNA demethylation: a lesson from the garden
Chromosoma, 2008Gene silencing by DNA methylation is well documented and known to be essential for various biological phenomena in many organisms. In contrast, the processes that convert the silent state of a gene whose DNA is methylated and predicted to form facultative heterochromatin to the actively transcribed state remain elusive.
Yoko, Ikeda, Tetsu, Kinoshita
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DNA demethylation and cancer: therapeutic implications
Cancer Letters, 2004The epigenome, which is comprised of chromatin and its associated proteins and the patterns of covalent modification of DNA by methylation, sets up and maintains gene expression programs. A hallmark of cancer is a paradoxical aberration of DNA methylation patterns, a global loss of DNA methylation, that coexists with regional hypermethylation of ...
Moshe, Szyf +2 more
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Science, 2011
Molecular Biology The methylation of DNA on cytosine (C) bases, most often at CpG sites, plays an important role in the epigenetic regulation of genomic imprinting, suppression of transposons and other parasitic DNA sequences, and X chromosome inactivation.
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Molecular Biology The methylation of DNA on cytosine (C) bases, most often at CpG sites, plays an important role in the epigenetic regulation of genomic imprinting, suppression of transposons and other parasitic DNA sequences, and X chromosome inactivation.
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Protein demethylation required for DNA methylation
Nature Genetics, 2009DNA methylation is an epigenetic mark directing stable, heritable gene silencing through development. A new study uncovers the importance of demethylation of the DNA methyltransferase-1 for maintenance of DNA methylation.
Hotz Hans-Rudolf, Peters Antoine H F M
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