Results 181 to 190 of about 60,603 (249)

Sex‐Modulated TACSTD2 Methylation and Hormone‐Receptor Axis Interactions in Glioblastoma: Insights Toward Mechanistic Understanding

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
Sex‐stratified analyses of the TCGA and CGGA cohorts have identified promoter‐proximal TACSTD2 CpG sites where methylation shows opposite survival associations in males and females, is independent of copy number, and correlates with TACSTD2 expression.
Tahreem Fatima
wiley   +1 more source

DNA demethylation mediated endogenous retroviruses transcription promotes aberrant T cell differentiation in systemic lupus erythematosus via RIG-I pathway. [PDF]

EBioMedicine
Min X, Yu Y, Hu Z, Ouyang L, Qiu Y, Zhao H, Wu J, Zou C, Zheng M, Yang S, Jia S, Yu D, Lu Q, Zhao M.   +13 more
europepmc   +1 more source

DNA Replication Stress‐Induced Transcriptome of Human Burkitt's Lymphoma Identifies Reciprocal Regulation Between MBD1 and BCL6 During Germinal Center‐Derived B‐Lymphomagenesis

Hematological Oncology, Volume 44, Issue 5, September 2026.
ABSTRACT BCL6 is a master transcriptional regulator of germinal center (GC) B cells. BCL6 is frequently translocated at the major translocation cluster (MTC) within intron 1 of the BCL6 locus, a hotspot commonly rearranged in diffuse large B cell lymphomas (DLBCLs).
Santosh Kumar Gothwal, Kyoko Oichai, Hongtae Kim, Kyungjae Myung, Jacqueline H. Barlow   +4 more
wiley   +1 more source

Developmental DNA demethylation is a determinant of neural stem cell identity and gliogenic competence. [PDF]

Sci Adv
MacArthur IC, Ma L, Huang CY, Bhavsar H, Suzuki M, Dawlaty MM.   +5 more
europepmc   +1 more source

Genomic Innovations in High‐Oil Soybean Breeding: Overcoming Yield Barriers and Climate Resilience Challenges

Legume Science, Volume 8, Issue 3, September 2026.
ABSTRACT Soybean (Glycine max L.) is the world's most important oilseed crop, supplying 25% of world‘s edible oil and 66% of feed protein. This review address genomic innovations to overcome yield constraints and climate vulnerability (especially drought stress) in high‐oil soybean breeding.
Mujeeb Ur Rehman, Muhammad Azam, Muhammad Ahsan, Azhar Iqbal, Lili Yu, Jhon Larzabal, Juan E. Rosas, Li‐Juan Qiu   +7 more
wiley   +1 more source

Young apple polyphenol extract prevents diabetic cognitive dysfunction by promoting TET2-mediated active DNA demethylation in the brain of diabetic mice. [PDF]

Front Nutr
Fang J, Zhang X, Qi Z, Zhou L, Chen Y, Li Q, Liu R, Yu H.   +7 more
europepmc   +1 more source

Prostate Cancer Development, Progression, and Therapy

MedComm – Oncology, Volume 5, Issue 3, September 2026.
This review provides an integrated overview of prostate cancer development, progression, and therapy, spanning historical milestones, molecular mechanisms, advanced research models, and emerging therapeutic strategies. It highlights recent advances in precision diagnosis, lineage plasticity, therapy resistance, and next‐generation treatments for ...
Xin Jin, Zicheng Xiao, Zexian Ding, Wei Li, Ruijiang Zeng, Yujun Shuai, Weimin Ci, Dan Xia, Xu Zhang, Haojie Huang   +9 more
wiley   +1 more source

Increasing TET Expression and 5‐Hydroxymethylcytosine Formation by a Carbocyclic 5‐Aza‐2′‐deoxy‐cytidine Antimetabolite

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
The carbocyclic Decitabine analog (cAzadC) incorporates as an antimetabolite weakly into the genome of growing tumor cells, where it triggers a genome‐wide demethylation and a surprisingly strong hydroxymethylation of cytosine, which translates into an efficient in vivo antitumor (AML) effect.
Maike Däther, Elsa Peev, Annika Fröhlich, Binje Vick, Sogol Fatourechi, Gilles Gasparoni, Matthias Heiss, Corinna C. Pleintinger, Emmanuel Asu Bisong, Hans Hurmiz, Davide Guglielminotti, Yasmin V. Gärtner, Tina Aumer, Karsten Spiekermann, Jörn Walter, Irmela Jeremias, Franziska R. Traube, Thomas Carell   +17 more
wiley   +2 more sources

DNA-demethylation by DAC induces <i>MAGE</i> expression and MAGE-specific T cell reactivity against tumors but also healthy cell subsets. [PDF]

Mol Ther Oncol
de Rooij MAJ, Meeuwsen MH, Wouters AK, Remst DFG, Hagedoorn RS, van der Steen DM, Verdegaal EME, Wachsmann TLA, Falkenburg JHF, Heemskerk MHM.   +9 more
europepmc   +1 more source

Contribution of One‐Electron Oxidation of Purine and Pyrimidine Bases to the Photo‐ and Radiation‐Induced Damage to Cellular DNA

ChemPhysChem, Volume 27, Issue 15, 14 August 2026.
One‐electron oxidation of purine and pyrimidine bases of isolated and cellular DNA generates related reactive base radical cations that are converted into final decomposition products through deprotonation and hydration. In the case of guanine, the most susceptible nucleobase to one‐electron oxidants, 8‐hydroxy‐7,8‐dihydroguanyl radical, thus formed by
Jean Cadet, Dimitar Angelov, Paolo DI Mascio, J. Richard Wagner   +3 more
wiley   +1 more source