Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells
Genome Biology, 2021 Background TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Since these oxidized methylcytosines (oxi-mCs) are not recognized by the
Atsushi Onodera +6 more
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Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription [PDF]
, 2014 TET enzymes are the epigenetic factors involved in the formation of the Sixth DNA base 5-hydroxymethylcytosine, whose deregulation has been associated with tumorigenesis.
Bacalini, MARIA GIULIA +9 more
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DNA Demethylation by TDG [PDF]
Epigenomics, 2012 DNA methylation has long been considered a very stable DNA modification in mammals that could only be removed by replication in the absence of remethylation - that is, by mere dilution of this epigenetic mark (so-called passive DNA demethylation). However, in recent years, a significant number of studies have revealed the existence of active processes ...
Shannon R, Dalton, Alfonso, Bellacosa
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The Influence of Hydroxylation on Maintaining CpG Methylation Patterns: A Hidden Markov Model Approach. [PDF]
PLoS Computational Biology, 2016 DNA methylation and demethylation are opposing processes that when in balance create stable patterns of epigenetic memory. The control of DNA methylation pattern formation by replication dependent and independent demethylation processes has been ...
Pascal Giehr +4 more
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Processive DNA demethylation via DNA deaminase-induced lesion resolution. [PDF]
PLoS ONE, 2014 Base modifications of cytosine are an important aspect of chromatin biology, as they can directly regulate gene expression, while DNA repair ensures that those modifications retain genome integrity. Here we characterize how cytosine DNA deaminase AID can
Don-Marc Franchini +8 more
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Reprogramming of the Hevea brasiliensis Epigenome and Transcriptome in Response to Cold Stress
Frontiers in Plant Science, 2022 Low temperature is a key factor limiting the rubber plantation extending to high latitude area. Previous work has shown that cold-induced DNA demethylation was coordinated with the expression of cold-responsive (COR) genes in Hevea brasiliensis.
Xiao Tang +5 more
doaj +1 more source
Active DNA Demethylation in Plants [PDF]
International Journal of Molecular Sciences, 2019 Methylation of cytosine (5-meC) is a critical epigenetic modification in many eukaryotes, and genomic DNA methylation landscapes are dynamically regulated by opposed methylation and demethylation processes. Plants are unique in possessing a mechanism for active DNA demethylation involving DNA glycosylases that excise 5-meC and initiate its replacement ...
Jara Teresa Parrilla-Doblas +3 more
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An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis [corrected]. [PDF]
PLoS Genetics, 2015 Active DNA demethylation in plants occurs through base excision repair, beginning with removal of methylated cytosine by the ROS1/DME subfamily of 5-methylcytosine DNA glycosylases.
Yan Li +8 more
doaj +1 more source
Dynamics of 5-methylcytosine and 5-hydroxymethylcytosine during pronuclear development in equine zygotes produced by ICSI [PDF]
, 2017 Background: Global epigenetic reprogramming is considered to be essential during embryo development to establish totipotency. In the classic model first described in the mouse, the genome-wide DNA demethylation is asymmetric between the paternal and the ...
De Schauwer, Catharina +3 more
core +1 more source
DNA demethylation by ROS1a in rice vegetative cells promotes methylation in sperm. [PDF]
, 2019 Epigenetic reprogramming is required for proper regulation of gene expression in eukaryotic organisms. In Arabidopsis, active DNA demethylation is crucial for seed viability, pollen function, and successful reproduction. The DEMETER (DME) DNA glycosylase
Fischer, Robert L +6 more
core +2 more sources