Results 31 to 40 of about 96,036 (271)
Blood Advances, 2017 : RUNX1 is an essential master transcription factor in hematopoietic development and plays important roles in immune functions. Although the gene regulatory mechanism of RUNX1 has been characterized extensively, the epigenetic role of RUNX1 remains ...
Takahiro Suzuki +8 more
doaj +1 more source
Rad50 mediates DNA demethylation to establish pluripotent reprogramming
Experimental and Molecular Medicine, 2020 Regenerative medicine: Protein boosts stem cell generation process Heightened expression of a DNA repair protein improves efficiency when generating induced pluripotent stem cells (iPSCs) for use in regenerative medicine.
Hanseul Park +2 more
doaj +1 more source
The DNA Repair Protein XRCC1 Functions in the Plant DNA Demethylation Pathway by Stimulating Cytosine Methylation (5-meC) Excision, Gap Tailoring, and DNA Ligation [PDF]
, 2013 Background: Active DNA demethylation in plants is initiated by 5-meC DNA glycosylases of the ROS1/DME family and continued through a base excision repair pathway.
Córdoba-Cañero, Dolores +3 more
core +1 more source
Nature Communications, 2021 Active DNA demethylation is required for sexual reproduction in plants, but the underlying mechanisms are unknown. Here, the authors show that the DNA glycosylases DEMETER and REPRESSOR OF SILENCING 1 enable the DNA demethylation-dependent activation of ...
Souraya Khouider +7 more
doaj +1 more source
Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain. [PDF]
, 2018 DNA methylation is an important epigenetic modification involved in gene regulation and transposable element silencing. Changes in DNA methylation can be heritable and, thus, can lead to the formation of stable epialleles. A well-characterized example of
Gallego-Bartolomé, Javier +8 more
core +2 more sources
Gemcitabine functions epigenetically by inhibiting repair mediated DNA demethylation.
PLoS ONE, 2010 Gemcitabine is a cytotoxic cytidine analog, which is widely used in anti-cancer therapy. One mechanism by which gemcitabine acts is by inhibiting nucleotide excision repair (NER).
Andrea Schäfer +4 more
doaj +1 more source
Epigenetic Changes during Hepatic Stellate Cell Activation. [PDF]
PLoS ONE, 2015 Hepatic stellate cells (HSC), which can participate in liver regeneration and fibrogenesis, have recently been identified as liver-resident mesenchymal stem cells.
Silke Götze +3 more
doaj +1 more source
Epigenetics & Chromatin, 2017 Background DNA methylation is a fundamental epigenetic modification that is involved in many biological systems such as differentiation and disease. We and others recently showed that some transcription factors (TFs) are involved in the site-specific ...
Takahiro Suzuki +6 more
doaj +1 more source
Nature Communications, 2021 The causal relationship between DNA demethylation and gene expression regulation has not yet been fully resolved. Here the authors develop a nuclease-dead Cas9 (dCas9) and gRNA site-specific targeting approach to physically block DNA methylation at ...
Daniel M. Sapozhnikov, Moshe Szyf
doaj +1 more source
Vitamin C Rescues in vitro Embryonic Development by Correcting Impaired Active DNA Demethylation
Frontiers in Cell and Developmental Biology, 2021 During preimplantation development, a wave of genome-wide DNA demethylation occurs to acquire a hypomethylated genome of the blastocyst. As an essential epigenomic event, postfertilization DNA demethylation is critical to establish full developmental ...
Meiqiang Chu +7 more
doaj +1 more source