Results 61 to 70 of about 96,036 (271)

DNA hydroxymethylation levels are altered in blood cells from Down syndrome persons enrolled in the MARK-AGE project [PDF]

, 2017
Down syndrome (DS) is caused by the presence of part or an entire extra copy of chromosome 21, a phenomenon that can cause a wide spectrum of clinically defined phenotypes of the disease. Most of the clinical signs of DS are typical of the ageing process
BACALINI, MARIA GIULIA, Breusing, Nicolle, Bürkle, Alexander, CAIAFA, Paola, CALABRESE, ROBERTA, Capri, Miriam, CICCARONE, FABIO, Franceschi, Claudio, Grune, Tilman, GUASTAFIERRO, Tiziana, Malavolta, Marco, Moreno villanueva, María, REALE, Anna, VALENTINI, ELISABETTA, ZAMPIERI, Michele   +14 more
core   +1 more source

DNA Methylation and Demethylation in Mammals [PDF]

Journal of Biological Chemistry, 2011
Cell type-specific DNA methylation patterns are established during mammalian development and maintained in adult somatic cells. Understanding how these patterns of 5-methylcytosine are established and maintained requires the elucidation of mechanisms for both DNA methylation and demethylation.
Chen, Zhao-xia, Riggs, Arthur D.
openaire   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. [PDF]

, 2015
Contrary to the long-held belief that DNA methylation of terminally differentiated cells is permanent and essentially immutable, post-mitotic neurons exhibit extensive DNA demethylation.
Coppola, Giovanni, Gao, Fuying, Geschwind, Daniel H, Guo, Junjie U, Ming, Guo-li, Shin, Jaehoon, Song, Hongjun, Su, Yijing, Weng, Yi-Lan, Yu, Huimei, Zhong, Chun   +10 more
core  

DNA methylation and demethylation dynamics

Oncotarget, 2015
DNA methylation is one of the most studied epigenetic modifications and is essential for mammalian development. The methylation pattern is established through an extremely orchestrated mechanism that implicates de novo methylation, maintenance of the methylated cytosine, and demethylation.
Neri, Francesco, INCARNATO, DANNY, OLIVIERO, Salvatore   +2 more
openaire   +2 more sources

Bacteria and Fungi Synergistically Reprogram Flavonoid Metabolites in the Pericarp of Citrus Reticulata 'Chachi' During Storage

Advanced Science, EarlyView.
The authors employed widely targeted metabolomics, microbial amplicon sequencing, and fermentation assays to investigate the microbiome 's influence on PCRC 's (pericarp of Citrus reticulata ' Chachi ') flavonoid profile over 0–19 years of storage. Based on the correlation analysis, solid‐state and liquid‐state fermentation, and catalytic activity ...
Jianmu Su, Sisheng Zhang, Lidi Liang, Haiyi Bai, Mei Bai, Hanjun He, Yayu Wang, Huan Liu, Xiangxiu Liang, Yu Sun, Hong Wu   +10 more
wiley   +1 more source

Friedreich ataxia patient tissues exhibit increased 5-hydroxymethylcytosine modification and decreased CTCF binding at the FXN locus [PDF]

, 2013
© 2013 Al-Mahdawi et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are ...
A Dürr, A Filla, A Saveliev, A Wong, AH Koeppen, Annalisa Pastore, C Sandi, Chiranjeevi Sandi, D Globisch, E Grabczyk, E Greene, E Kim, GN Filippova, H Chen, H Holemon, H Stroud, I Castaldo, I De Biase, I De Biase, J Robertson, JL Bradley, JU Guo, KE Szulwach, M Mellén, M Pandolfo, M Tahiliani, Mark A. Pook, MC Haffner, MR Branco, MV Evans-Galea, N Chia, PK Chan, R Sharma, RD Wells, Ricardo Mouro Pinto, S Al-Mahdawi, S Kriaucionis, Sahar Al-Mahdawi, T Wang, V Campuzano, V Campuzano, Y Huang   +41 more
core   +7 more sources

An Extended Culture System that Supports Human Primordial Germ Cell-like Cell Survival and Initiation of DNA Methylation Erasure. [PDF]

, 2020
The development of an in vitro system in which human primordial germ cell-like cells (hPGCLCs) are generated from human pluripotent stem cells (hPSCs) has been invaluable to further our understanding of human primordial germ cell (hPGC) specification ...
Bower, Grace, Chialastri, Alex, Clark, Amander T, Dey, Siddharth S, Gell, Joanna J, Hancock, Grace, Liu, Wanlu, Sosa, Enrique, Tao, Yu, Wamaitha, Sissy E   +9 more
core  

Retinoblastoma makes its mark on imprinting in plants [PDF]

, 2008
Genomic imprinting results in the preferential expression of alleles from either the maternal or paternal chromosomes. This epigenetic process occurs in embryonic and extra-embryonic (placental) tissues of mammals, but only in the extra-embryonic ...
Liliana M Costa, José F Gutierrez-Marcos, Wolf, Youngson, Spillane, Kermicle, Feil, Delaval, Bourc&apos, Schoenherr, Mager, Lewis, Gutierrez-Marcos, Kinoshita, Jullien, Choi, Morales-Ruiz, Reik, McCabe, Jung, Ebel, Hennig, Guitton, Ingouff, Jullien, Kimura, Rossi, Wu, Mathieu, Wu   +29 more
core   +2 more sources

DNA demethylation in erythroleukaemia cells

FEBS Letters, 1990
Despite a fall in the proportion of CGs methylated, evidence has not been obtained for significant demethylation of prelabelled DNA when mouse erythroleukaemia cells are induced to differentiate. There is, however, a delay in the methylation of the DNA that is synthesised in the early period of induction, leading to its undermethylation by 30–50% and ...
Adams, R.L.P., Hanley, A., Rinaldi, A.
openaire   +2 more sources