Results 121 to 130 of about 2,368,060 (250)

Classified for SoA 2015-16

, 2015
Vacancy notification for School of Architecture A.Y.
DNA
core  

Editing DNA methylation in vivo

Nature Communications
DNA methylation is a crucial epigenetic mechanism that regulates gene expression. Precise editing of DNA methylation has emerged as a promising tool for dissecting its biological function. However, challenges in delivery have limited most applications of
Richard Pan, Jingwei Ren, Xinyue Chen, Luis F. Flores, Rachel V. L. Gonzalez, Andre Antonio Adonnino, Brandon Lofts, Jennifer Waldo, Julian Halmai, Orrin Devinsky, Kyle Fink, X. Shawn Liu   +11 more
doaj   +1 more source

Chloroplast and mitochondrial DNA editing in plants. [PDF]

Nat Plants, 2021
Kang BC, Bae SJ, Lee S, Lee JS, Kim A, Lee H, Baek G, Seo H, Kim J, Kim JS.   +9 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Enhanced mitochondrial DNA editing in mice using nuclear-exported TALE-linked deaminases and nucleases. [PDF]

Genome Biol, 2022
Lee S, Lee H, Baek G, Namgung E, Park JM, Kim S, Hong S, Kim JS.   +7 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Recent advances in DNA-free editing and precise base editing in plants

, 2017
Genome-editing technologies based on the CRISPR (clustered regularly interspaced short palindromic repeat) system have been widely used in plants to investigate gene function and improve crop traits.
Yi Zhang, Caixia Gao
core   +1 more source

Precision gene editing: The power of CRISPR-Cas in modern genetics

Molecular Therapy: Nucleic Acids
Gene editing has transformed molecular biology by enabling precise modifications to genomic DNA across a wide variety of organisms. Gene editing technologies make it possible to add, remove, or modify specific DNA sequences, with a range of applications ...
Jeong H. Joo, Soogene Lee, Keun P. Kim
doaj   +1 more source

Nuclear and mitochondrial DNA editing in human cells with zinc finger deaminases. [PDF]

Nat Commun, 2022
Lim K, Cho SI, Kim JS.
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source