Results 171 to 180 of about 888,680 (335)

Epitranscriptome-wide profiling identifies RNA editing events regulated by ADAR1 that are associated with DNA repair mechanisms in human TK6 cells

Frontiers in Genetics
IntroductionAdenosine-to-Inosine (A-to-I) editing is an endogenous RNA modification in eukaryotes, catalyzed by adenosine deaminases acting on RNA (ADARs). This modification modulates the gene expression by influencing splicing, RNA stability, and coding
Akito Yoshida, Yuqian Song, Hotaru Takaine, Sujin Song, Nonoka Konishi, Yu-Hsien Hwang-Fu, Zachary Johnson, Kiyoe Ura, Akira Sassa   +8 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Precise detection of differential RNA editing sites across varied biological conditions using the CADRES pipeline

Scientific Reports
RNA editing is an important post-transcriptional modification for gene regulation and protein diversity. Detecting these modifications, especially Differential Variants on RNA (DVRs), presents significant challenges due to interference from sequencing ...
Jun Sun, Chi Zhang, Xiuling Li
doaj   +1 more source

Precision gene editing: The power of CRISPR-Cas in modern genetics

Molecular Therapy: Nucleic Acids
Gene editing has transformed molecular biology by enabling precise modifications to genomic DNA across a wide variety of organisms. Gene editing technologies make it possible to add, remove, or modify specific DNA sequences, with a range of applications ...
Jeong H. Joo, Soogene Lee, Keun P. Kim
doaj   +1 more source

CRISPR-Free Mitochondrial DNA Base Editing [PDF]

The CRISPR Journal, 2020
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Characterization of the genome editing with miniature DNA nucleases TnpB and IscB in Escherichia coli strains

Communications Biology
DNA endonucleases TnpB and IscB are emerging candidates for combating drug-resistant bacteria, particularly Escherichia coli, due to their specificity in targeting DNA and smaller size. However, the genome-editing of TnpB/IscB in E. coli remains unclear.
Hongjie Tang, Jie Gao, Hengyi Wang, Mingjun Sun, Suyi Zhang, Chuan Song, Qi Li   +6 more
doaj   +1 more source

Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite

, 2020
R. L. Reddick, G. C. Kujoth, Y. Wada, T. A. Prolla, N. Maeda, H.-S. Kim, R. Fox, O. Smithies, S. Tsutsumi   +8 more
openalex   +1 more source

CRISPR-Directed In Vitro Gene Editing of Plasmid DNA Catalyzed by Cpf1 (Cas12a) Nuclease and a Mammalian Cell-Free Extract [PDF]

, 2018
Brett M. Sansbury, Amanda M. Wagner, Erez Nitzan, Gabi Tarcic, Eric B. Kmiec   +4 more
openalex   +1 more source

Publisher Correction: Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction [PDF]

, 2020
Paul R. Marshall, Qiongyi Zhao, Xiang Li, Wei Wei, Ambika Periyakaruppiah, Esmi L. Zajaczkowski, Laura J. Leighton, Sachithrani U. Madugalle, Dean Basic, Ziqi Wang, Jiayu Yin, Wei‐Siang Liau, Ankita Gupte, Carl R. Walkley, Timothy W. Bredy   +14 more
openalex   +1 more source