Results 161 to 170 of about 2,368,060 (250)

Structure-guided engineering of AI-derived adenine base editors for nuclear and mitochondrial DNA editing. [PDF]

Nucleic Acids Res
Hwang HY, Mariam N, Kweon J, Yi H, Jang G, Roh J, Lim K, Park JH, Kim Y, Kim D.   +9 more
europepmc   +1 more source

MagnEdit-interacting factors that recruit DNA-editing enzymes to single base targets. [PDF]

Life Sci Alliance, 2020
McCann JL, Salamango DJ, Law EK, Brown WL, Harris RS.   +4 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Emerging trends in gene and cell therapy: CRISPR in DNA editing and beyond. [PDF]

Cell Rep Med
Ji R, Chen Q, Zhang Y.
europepmc   +1 more source

Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors. [PDF]

Nat Biotechnol, 2020
Doman JL, Raguram A, Newby GA, Liu DR.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Beyond DNA editing: how Cas13 redefined programmable RNA manipulation and what still limits its therapeutic promise. [PDF]

Nucleic Acids Res
Hou S, Bi W, Liu W, Nie H, Jiang J, Zeng L.   +5 more
europepmc   +1 more source

SpCas9- and LbCas12a-Mediated DNA Editing Produce Different Gene Knockout Outcomes in Zebrafish Embryos. [PDF]

Genes (Basel), 2020
Meshalkina DA, Glushchenko AS, Kysil EV, Mizgirev IV, Frolov A.   +4 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

An engineered mitoCBE facilitates efficient mitochondrial DNA editing and modified mitochondrial transfer. [PDF]

Mol Ther
Liu J, Chen J, Huang S, Guo J, Li X, Yan Y, Chen R, Li G, Liu M, Wei J, Huang X, Qiao Y.   +11 more
europepmc   +1 more source