Translesion synthesis and microhomology-mediated end-joining repair in trypanosomatids. [PDF]
PLoS Negl Trop DisDrogalis Beckham L +3 more
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Microhomology-mediated end joining is the predominant form of DNA repair in the mosquito Aedes aegypti with implications for gene editing, gene drive, and transgene removal. [PDF]
Nucleic Acids ResRomanowski JS, Myles KM, Adelman ZN.
europepmc +1 more source
Dysregulation of the DNA repair‑immune axis: Targeted therapeutic strategies for autoimmune diseases (Review). [PDF]
Int J Mol MedWan K +11 more
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Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway
Annual Review of Biochemistry, 2021DNA double-strand breaks pose a serious threat to genome stability. In vertebrates, these breaks are predominantly repaired by nonhomologous end joining (NHEJ), which pairs DNA ends in a multiprotein synaptic complex to promote their direct ligation. NHEJ is a highly versatile pathway that uses an array of processing enzymes to modify damaged DNA ends ...
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Bacterial DNA repair by non-homologous end joining
Nature Reviews Microbiology, 2007The capacity to rectify DNA double-strand breaks (DSBs) is crucial for the survival of all species. DSBs can be repaired either by homologous recombination (HR) or non-homologous end joining (NHEJ). The long-standing notion that bacteria rely solely on HR for DSB repair has been overturned by evidence that mycobacteria and other genera have an NHEJ ...
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Repair of DNA double strand breaks by non-homologous end joining
Biochimie, 2003DNA double strand breaks (DSB) are the most serious form of DNA damage. If not repaired they can lead to cell death. If misrepaired DSBs contribute to chromosomal aberrations and genomic instability. Non-homologous end joining (NHEJ) is one of two major pathways for the repair of DSBs in human cells.
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The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway [PDF]
Annual Review of Biochemistry, 2010 Double-strand DNA breaks are common events in eukaryotic cells, and there are two major pathways for repairing them: homologous recombination (HR) and nonhomologous DNA end joining (NHEJ). The various causes of double-strand breaks (DSBs) result in a diverse chemistry of DNA ends that must be repaired.
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Regulation of DNA repair in the absence of classical non-homologous end joining
DNA Repair, 2018Classical non-homologous end-joining (cNHEJ) is the main pathway for the repair of DNA double strand breaks (DSBs) in mammalian cells. In the absence of c-NHEJ, an alternative end-joining (A-EJ) mechanism resolves DSBs. To date, no A-EJ specific factor has been identified. Instead, this mechanism appears to co-opt proteins involved in more than one DNA
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Non-homologous DNA end joining and alternative pathways to double-strand break repair [PDF]
Nature Reviews Molecular Cell Biology, 2017 DNA double-strand breaks (DSBs) are the most dangerous type of DNA damage because they can result in the loss of large chromosomal regions. In all mammalian cells, DSBs that occur throughout the cell cycle are repaired predominantly by the non-homologous DNA end joining (NHEJ) pathway. Defects in NHEJ result in sensitivity to ionizing radiation and the
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Function of ATM and MSH2 during nonhomologous end joining in DNA repair
The Journal of Immunology, 2022Abstract Class switch recombination (CSR) produces secondary immunoglobulin isotypes and requires AID-dependent DNA deamination of intronic switch (S) regions within the immunoglobulin heavy chain gene locus. Non-canonical repair of deaminated DNA by mismatch repair (MMR) or base excision repair (BER) creates DNA breaks that permit ...
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