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Ubiquitylation of Ku80 by RNF126 Promotes Completion of Nonhomologous End Joining-Mediated DNA Repair [PDF]

Molecular and Cellular Biology, 2017
Repair of damaged DNA is critical for maintenance of genetic information. In eukaryotes, DNA double-strand breaks (DSBs) are recognized by the Ku70-Ku80 heterodimer, which then recruits proteins that mediate repair by nonhomologous end joining (NHEJ). Prolonged retention of Ku70/80 at DSBs prevents completion of repair, however, with ubiquitylation of ...
Noriko Ishida, Tadashi Nakagawa, Hiroki Shima   +2 more
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Role for non-homologous end-joining in the repair of UVA-induced DNA damage

International Journal of Radiation Biology, 2002
The biological significance of long-wavelength ultraviolet (UV) light, UVA, is increasingly realized, but the precise nature of the cellular damage responsible for the effects of this radiation is still not clear. It has been reported that UVA can induce double-strand breaks in DNA, but the biological significance of these is not known.
L J, Fell, N D, Paul, T J, McMillan
openaire   +2 more sources

Emerging models for DNA repair: Dictyostelium discoideum as a model for nonhomologous end-joining

DNA Repair, 2014
DNA double strand breaks (DSBs) are a particularly cytotoxic variety of DNA lesion that can be repaired by homologous recombination (HR) or nonhomologous end-joining (NHEJ). HR utilises sequences homologous to the damage DNA template to facilitate repair.
Catherine J, Pears, Nicholas D, Lakin
openaire   +2 more sources

Multiple end joining mechanisms repair a chromosomal DNA break in fission yeast

DNA Repair, 2012
Non-homologous end joining (NHEJ) is an important mechanism for repairing DNA double-strand breaks (DSBs). The fission yeast Schizosaccharomyces pombe has a conserved set of NHEJ factors including Ku, DNA ligase IV, Xlf1, and Pol4. Their roles in chromosomal DSB repair have not been directly characterized before.
Peng, Li, Jun, Li, Ming, Li, Kun, Dou, Mei-Jun, Zhang, Fang, Suo, Li-Lin, Du   +6 more
openaire   +2 more sources

Mechanism of DNA double-strand break repair by non-homologous end joining

DNA Repair, 2005
The repair of DNA double-strand breaks (DSBs) is critical for maintaining genome stability. Although the non-homologous end joining (NHEJ) pathway frequently results in minor changes in DNA sequence at the break site and occasionally the joining of previously unlinked DNA molecules, it is a major contributor to cell survival following exposure of ...
Melissa L, Hefferin, Alan E, Tomkinson
openaire   +2 more sources

Deletion of yeast TPK1 reduces the efficiency of non-homologous end joining DNA repair

Biochemical and Biophysical Research Communications, 2020
Non-homologous end joining (NHEJ) is a highly conserved mechanism of DNA double-stranded break (DSB) repair. Here we utilize a computational protein-protein interaction method to identify human PRKACB as a potential candidate interacting with NHEJ proteins.
Mohsen Hooshyar, Matthew Jessulat, Daniel Burnside, Anna Kluew, Mohan Babu, Ashkan Golshani   +5 more
openaire   +2 more sources

DNA polymerase μ is a global player in the repair of non-homologous end-joining substrates

DNA Repair, 2012
The specialized DNA polymerase μ (pol μ) intervenes in the repair mechanism non-homologous end-joining (NHEJ) as an end-processing factor but its role has not been fully elucidated. Pol μ has been shown to participate in DNA synthesis at junctions in vitro, including on unpaired substrates, and to promote annealing.
Chayot, Romain, Montagne, Benjamin, Ricchetti, Miria   +2 more
openaire   +2 more sources

Involvement of the Nonhomologous End Joining DNA Repair Pathway in the Bystander Effect for Chromosomal Aberrations

Radiation Research, 2003
Cells of mouse knockout cell lines for Ku80 (now known as Xrcc5), Ku70 (now known as G22p1), DNA-PKcs (now known as Prkdc) and PARP (now known as Adprt) were synchronized in G1 phase and exposed to very low fluences of alpha particles. The frequency of gross chromosomal aberrations was scored at the first postirradiation metaphase.
John B, Little, Hatsumi, Nagasawa, Gloria C, Li, David J, Chen   +3 more
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Repairing DNA double-strand breaks by the prokaryotic non-homologous end-joining pathway

Biochemical Society Transactions, 2009
The NHEJ (non-homologous end-joining) pathway is one of the major mechanisms for repairing DSBs (double-strand breaks) that occur in genomic DNA. In common with eukaryotic organisms, many prokaryotes possess a conserved NHEJ apparatus that is essential for the repair of DSBs arising in the stationary phase of the cell cycle. Although the bacterial NHEJ
Nigel C, Brissett, Aidan J, Doherty
openaire   +2 more sources

DNA repair | Nonhomologous End-Joining in Bacteria

2021
Annabelle Thibessard, Claire Bertrand, Edward J. Bartlett, Aidan J. Doherty, Claude Bruand, Pierre Leblond, François Lecointe   +6 more
openaire   +3 more sources