Results 101 to 110 of about 846,282 (296)
Modified acid guanidinium thiocyanate- phenol -chloroform RNA extraction method which greatly reduces DNA contamination [PDF]
, 1993 Paul D. Siebert, Alex Chenchik
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Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
DNA extraction: Campylobacter v1 [PDF]
, 2019 Protocol for DNA extraction from Campylobacter isolates using the QIAGEN QIAamp DNA Mini Kit (QIAGEN, Crawley, UK).
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Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
A simple method for extraction of DNA from Guthrie cards. [PDF]
, 1992 Christian Schneeberger +4 more
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, 2021 This protocol details how to extract DNA from agarose gel using Thermo Scientific GeneJET Gel Extraction Kit. This is suitable for gels run in either TAE or TBE buffer, and for DNA fragments from 25 bp to 20 kb. The extraction is performed using spin columns.
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Molecular Oncology, EarlyView.In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton +17 more
wiley +1 more source
Improved RAPD amplification of recalcitrant plant DNA by the use of activated charcoal during DNA extraction [PDF]
, 1996 I. Vroh Bi +4 more
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Extraction and PCR of DNA From Parasitoid Wasps That Have Been Chemically Dried [PDF]
, 1997 Andrew D. Austin, Natalie Dillon
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