Results 71 to 80 of about 222,504 (300)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Aspirin-induced DNA fragmentation.
, 2013 DNA was isolated from GSH-depleted and NAC treated cells after treatment with different doses of ASA as described in the Materials and Methods. DNA fragmentation was studied using 1.5% agarose gel electrophoresis and visualized by ethidium bromide ...
Haider Raza (324458) +1 more
core +1 more source
Sperm DNA and detection of DNA fragmentations in sperm [PDF]
Urology Research and Practice, 2019 Abstract The questionable effectiveness of routine sperm parameters in determining male factor infertility problems and increasing the success rates of assisted reproductive techniques have led to the investigation of more detailed sperm parameters that could affect the male fertility and reproduction.
openaire +2 more sources
Italian Journal of Animal Science, 2010 Ochratoxin A is a mycotoxin responsible for disease states in both humans and animals. OTA mechanisms of action are numerous, including lipid peroxidation. Oxidative damage results in the modification of macromolecules (i.e.
Antonella Baldi +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Association of age with sperm DNA fragmentation [PDF]
, 2011 Artículo de publicación ISIBackground: There is an association between aging and an increased number of sperms with alterations in nuclear DNA. Aim: To study the association between age and fragmentation of sperm DNA.
Smith Garcés, Rosita +4 more
core
Sperm nuclear DNA fragmentation in adolescents with varicocele
, 2006 Objective: To verify if sperm from adolescents with varicocele have an increased rate of DNA fragmentation when compared with adolescents without varicocele.Design: Controlled prospective study.Setting: Patients in an academic research environment ...
Bertolla, Ricardo Pimenta [UNIFESP] +5 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Sperm DNA fragmentation and male subfertility
, 2012 The aims of the present study were to investigate whether: 1. There is a difference in sperm DNA fragmentation between subfertile men and fertile controls. 2. Sperm DNA fragmentation differs among men with different causes of subfertility. 3.
Κανταρτζή, Περσεφόνη-Δήμητρα +1 more
core +1 more source