Results 51 to 60 of about 222,504 (300)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

DNA methylation analysis explores the molecular basis of plasma cell-free DNA fragmentation

, 2023
Plasma cell-free DNA (cfDNA) are small molecules generated through a non-random fragmentation procedure. Despite commendable translational values in cancer liquid biopsy, however, the biology of cfDNA, especially the principles of cfDNA fragmentation ...
Zhao, Yu, Xin Zhao, Li Ma, Kun Sun, Shuowen Zhang, Wu, Xiang’an, Jin, Xin, Zhang, Shuowen, Ziteng Zhang, Xin Hong, Ma, Li, Xiang’an Wu, Xia, Zhaohua, Xu, Gang, Shunda Du, Xin Jin, Zhao, Xin, Du, Shunda, Mengqi Yang, Hong, Xin, Zhaohua Xia, An, Yunyun, Sun, Kun, Yunyun An, Gang Xu, Yang, Mengqi, Zhang, Ziteng, Yu Zhao   +27 more
core   +1 more source

Генетические факторы нарушения сперматогенеза у мужчин со сниженной репродуктивной функцией

Фактори експериментальної еволюції організмів, 2014
Aims. The correlation of DNA fragmentation level with classic sperm parameters, the male age and the level of immature spermatozoa and sperm aneuploidies was investigated. Methods.
Е. С. Жилкова, А. М. Феськов, И. М. Безпечная, А. М. Федота   +3 more
doaj  

Study Protocol: Comparison of Clinical Pregnancy Outcomes of Intracytoplasmic Sperm Injection (ICSI) Using Testicular and Ejaculated Spermatozoa in Male Patients with High DNA Fragmentation

Journal of Pharmacy and Bioallied Sciences
Background: This study aims to compare the clinical pregnancy outcome of intracytoplasmic sperm injection (ICSI) using testicular and ejaculated spermatozoa in male patients with high deoxyribonucleic acid (DNA) fragmentation.
Juhi Barai, Akash More, Namrata Choudhary   +2 more
doaj   +1 more source

Relationship between sperm progressive motility and DNA integrity in fertile and infertile men

Middle East Fertility Society Journal, 2018
Background: Progressive sperm motility was found to be predictive for in vitro and in vivo fertilization. There has been an increase in the literature of studies investigating whether DNA fragmentation could be associated with other semen parameters ...
Salah Elbashir, Yasmin Magdi, Ayman Rashed, Mohamed Ahmed Ibrahim, Yehia Edris, Ahmed Mostafa Abdelaziz   +5 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Dynamics of sperm DNA fragmentation in domestic animals - II. The stallion

, 2007
The mixed success of equine artificial insemination programs using chilled and frozen-thawed semen is most likely associated with the variable response of the sperm cell to the preservation process and the fact that stallions are not selected on the ...
P. Arana, Arroyo, F., Arroyo, Francisca, Gosalvez, Jaime, J. Gosálvez, F. Arroyo, Arana Montes, María Del Pilar De, Lopez-Fernandez, Carmen, C. López-Fernández, F. Crespo, S.D. Johnston, Crespo Castejón, Francisco, Gosalvez, J., Johnston, Stephen Douglas, Lopez-Fernandez, C., Fernandez, J. L., Arana, P., Fernandez, José Luis, Crespo, F., Johnston, S. D., J.L. Fernández   +20 more
core   +1 more source

EndoG links Bnip3-induced mitochondrial damage and caspase-independent DNA fragmentation in ischemic cardiomyocytes.

PLoS ONE, 2011
Mitochondrial dysfunction, caspase activation and caspase-dependent DNA fragmentation are involved in cell damage in many tissues. However, differentiated cardiomyocytes repress the expression of the canonical apoptotic pathway and their death during ...
Jisheng Zhang, Junmei Ye, Albert Altafaj, Maria Cardona, Núria Bahi, Marta Llovera, Xavier Cañas, Stuart A Cook, Joan X Comella, Daniel Sanchis   +9 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

DNA fragmentation in placenta of infected mice.

, 2013
A: Placenta of P. berghei infected mice showing distinct DNA fragmentation on day 4 and 6 PI respectively compared with DNA of normal placenta. B: No DNA fragmentation observed in blood from infected and normal mouse.
Geeta Shukla (330926), Lalita Sharma (330925), Jagdeep Kaur (103037)   +2 more
core   +1 more source