Results 41 to 50 of about 1,932,999 (290)
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Codeine-induced sperm DNA damage is mediated predominantly by oxidative stress rather than apoptosis
Redox Report, 2020 Background: Opioids have been implicated to induce infertility. Although codeine remains the most used opioid for recreational purpose, no study has documented its effect on sperm quality.
Ayodeji Folorunso Ajayi +1 more
doaj +1 more source
BMC Genomics, 2022 Background Novel commercial kits for whole genome library preparation for next-generation sequencing on Illumina platforms promise shorter workflows, lower inputs and cost savings. Time savings are achieved by employing enzymatic DNA fragmentation and by
Teodora Ribarska +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
A perspective on sperm DNA fragmentation [PDF]
Translational Andrology and Urology, 2017 The paper on sperm DNA fragmentation by Ashok Agarwal et al . summarizes the currently available DNA fragmentation tests and discusses the role of sperm function tests in the intracytoplasmic sperm injection (ICSI) era (1). The authors have summarized the clinical utility of sperm DNA fragmentation test and have provided recommendations based on ...
Pandiyan, Natarajan +2 more
openaire +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2016 Total DNA fragmentation index (tDFI) and high DNA stainability (HDS) results obtained by Sperm Chromatin Structure Assay (SCSA)
Eduardo R. S. Roldan (191494) +11 more
core +1 more source
Генетические факторы нарушения сперматогенеза у мужчин со сниженной репродуктивной функцией
Фактори експериментальної еволюції організмів, 2014 Aims. The correlation of DNA fragmentation level with classic sperm parameters, the male age and the level of immature spermatozoa and sperm aneuploidies was investigated. Methods.
Е. С. Жилкова +3 more
doaj
Journal of Pharmacy and Bioallied SciencesBackground: This study aims to compare the clinical pregnancy outcome of intracytoplasmic sperm injection (ICSI) using testicular and ejaculated spermatozoa in male patients with high deoxyribonucleic acid (DNA) fragmentation.
Juhi Barai +2 more
doaj +1 more source