Results 61 to 70 of about 222,504 (300)

Study Protocol: Effect of Lifestyle Modification on Sperm DNA Fragmentation Index

Journal of Pharmacy and Bioallied Sciences
Background: Infertility is a growing concern, affecting 8%–12% of reproductive-age couples worldwide. Male infertility accounts for 20%–30% of cases and contributes to 50% of fertility problems.
Neha Nawale, Akash More, Namrata Anjankar, Sanket Mahajan, Radha Bondare   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

TUNEL assay—Standardized method for testing sperm DNA fragmentation

, 2021
Sperm DNA integrity is important for normal functions such as fertilization, implantation, pregnancy and fetal development. Sperm DNA fragmentation (SDF) is more common in infertile men and may be responsible for poor reproductive function.
Iovine, C, Henkel, R, Sharma, R
core   +1 more source

Fragmentation Through Polymerization (FTP): A new method to fragment DNA for next-generation sequencing.

PLoS ONE, 2019
Fragmentation of DNA is the very important first step in preparing nucleic acids for next-generation sequencing. Here we report a novel Fragmentation Through Polymerization (FTP) technique, which is a simple, robust, and low-cost enzymatic method of ...
Konstantin B Ignatov, Konstantin A Blagodatskikh, Dmitry S Shcherbo, Tatiana V Kramarova, Yulia A Monakhova, Vladimir M Kramarov   +5 more
doaj   +1 more source

Can Altered Expression of HSPA2 in Varicocele Patients Lead to Abnormal Spermatogenesis? [PDF]

International Journal of Fertility and Sterility, 2010
Background Heat shock protein A2 (HSPA2) is correlated with sperm maturity and function. Therefore, dysfunctional expression of this gene results in abnormal spermatogenesis.
Mohammad Hossein Nasr Esfahani, Homayoun Abbasi, Zahra Mirhosseini, Nazem Ghasemi, Shahnaz Razavi, Marziyeh Tavalaee, Somayeh Tanhaei, Mohammad Reza Deemeh, Kamran Ghaedi, Farzaneh Zamansoltani, Farzad Rajaei   +10 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Correlation of Sperm Parameters With Sperm DNA Damage or Sperm Nucleus Chromatin Status in Oligospermic Individuals Referred to Qom Jihad Daneshgahi Infertility Treatment Center in 2017 (Iran)

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2021
Background and Objective: Although proper morphology and motility of sperm can be one of the most important factors influencing male fertility, however, these parameters cannot play a decisive role in the health of sperm DNA.
Atefeh Verdi, Mohammad Hossein Nasr-Esfahani, Mohsen Forozanfar, Marziyeh Tavalaee   +3 more
doaj  

Features of structure and dynamics in damages of fertile properties in ejaculate under the influence of toxocariasis invasion

Сучасні медичні технології, 2020
Purpose of the study. To study the features of changes of spermiologic values and degree of spermatozoa DNA fragmentation depending on the presence/absence of toxocariasis invasion. Materials and methods.
L. L. Voroncova, S. O. Kenijz, V. A. Kovalenko   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The effect of two pre-cryopreservation single layer colloidal centrifugation protocols in combination with different freezing extenders on the fragmentation dynamics of thawed equine sperm DNA

, 2012
Variability among stallions in terms of semen cryopreservation quality renders it difficult to arrive at a standardized cryopreservation method. Different extenders and processing techniques (such us colloidal centrifugation) are used in order to ...
Fernández, Alvaro, Gosálvez Berenguer, Jaime, Serres Dalmau, María Consolacion, Gutiérrez Cepeda, Luna, Crespo Castejón, Francisco, Ramírez, Miguel Ángel   +5 more
core   +1 more source