Results 81 to 90 of about 373,852 (297)

A computational method for estimating the PCR duplication rate in DNA and RNA-seq experiments. [PDF]

, 2017
BackgroundPCR amplification is an important step in the preparation of DNA sequencing libraries prior to high-throughput sequencing. PCR amplification introduces redundant reads in the sequence data and estimating the PCR duplication rate is important to
Bansal, Vikas
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

A non extensive approach for DNA breaking by ionizing radiation [PDF]

, 2002
Tsallis entropy and a maximum entropy principle allows to reproduce experimental data of DNA double strand breaking by electron and neutron radiation.
Antoranz, JC, Arruda Neto, JDT, Deepman, A, Guzman, F, Rodgers, GJ, Rodriguez, O, Sotolongo-Costa, O   +6 more
core   +1 more source

Robust self-replication of combinatorial information via crystal growth and scission [PDF]

, 2012
Understanding how a simple chemical system can accurately replicate combinatorial information, such as a sequence, is an important question for both the study of life in the universe and for the development of evolutionary molecular design techniques ...
B. Yurke, Bullard, Cairns-Smith, Carnall, Collins, Deck, Dutta, E. Winfree, Huppa, Johnston, Knowles, Mao, Orgel, Paul, R. Schulman, Rasmussen, Rothemund, Rothemund, Rubinov, Schrum, Seeman, Smalley, Smith, Viedma, Wang, Wang, Winfree, Wochner   +27 more
core   +3 more sources

Evidence based sperm DNA fragmentation [PDF]

Translational Andrology and Urology, 2017
Male factor infertility is an important and current issue in the field of human reproduction. The prevalence of male factor associated infertility is increasing with almost 50% of all cases of fertility treatments being linked to this factor (1). Moreover, the introduction of intracytoplasmic sperm injection (ICSI) in 1992 (2) offered, for patients ...
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Evaluation of bisulfite kits for DNA methylation profiling in terms of DNA fragmentation and DNA recovery using digital PCR.

PLoS ONE, 2018
DNA methylation is one of the most important epigenetic modifications in the regulation of gene transcription. The current gold standard to study this modification is bisulfite sequencing.
Sam Kint, Ward De Spiegelaere, Jonas De Kesel, Linos Vandekerckhove, Wim Van Criekinge   +4 more
doaj   +1 more source

Correlation of sperm DNA damage with blastocyst formation: systematic review and meta-analysis

Middle East Fertility Society Journal, 2021
Background The routine semen analysis fails to detect sperm DNA damage which contributes to the majority of male factor infertility. Sperm DNA fragmentation test (DFI) measures the sperm DNA damage. Blastocyst formation is an important step in IVF ± ICSI.
Prashanth K. Adiga, Srisailesh Vitthala, Shivaranjeni   +2 more
doaj   +1 more source

Long range correlations in DNA : scaling properties and charge transfer efficiency [PDF]

, 2003
We address the relation between long range correlations and charge transfer efficiency in aperiodic artificial or genomic DNA sequences. Coherent charge transfer through the HOMO states of the guanine nucleotide is studied using the transmission approach,
Dominique Bicout, Efim Kats, Enrique Maciá, H. E. Hurst, M. Di Ventra, P. Carpena, Stephan Roche, W. Feller, W. Li   +8 more
core   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source