Results 91 to 100 of about 1,932,999 (290)
Gains from Fragmentation at the Firm Level: Evidence from Japanese Multinationals in East Asia [PDF]
The unprecedented development of production networks in East Asia has been investigated, both theoretically and empirically, employing the conceptual framework of fragmentation theory and its extensions.
Toshiyuki Matsuura +2 more
core +2 more sources
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Stacking interactions in denaturation of DNA fragments [PDF]
The European Physical Journal E, 2011 A mesoscopic model for heterogeneous DNA denaturation is developed in the framework of the path integral formalism. The base pair stretchings are treated as one-dimensional, time dependent paths contributing to the partition function. The size of the paths ensemble, which measures the degree of cooperativity of the system, is computed versus ...
openaire +4 more sources
Анализ связи фрагментации ДНК и анеуплоидий спермы с параметрами ранних эмбрионов
Фактори експериментальної еволюції організмів, 2016 Aim. The dependence of the process of blastocyst formation in IVF practice on the level of sperm DNA fragmentation and sperm aneuploidies in men with low reproductive function was studied. Methods.
Е. С. Жилкова +4 more
doaj
The role of oxidative stress in male infertility: Connection to sperm telomere shortening and overall DNA damage [PDF]
Arhiv za farmacijuMale infertility affects approximately 20% of men, with 30-40% of cases being linked to issues in both partners. While sperm production may be normal, DNA damage in spermatozoa can occur and become a primary cause of infertility.
Glišić Biljana +1 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
SPERM DNA FRAGMENTATION IN INFERTILE MEN OF KUZBASS
Мать и дитя в Кузбассе, 2022 The standard method for diagnosing male infertility involves a spermogram, which does not always give a complete picture of male fertility. One additional method for assessing ejaculate is the sperm DNA fragmentation test (SDF), which determines the ...
Алексей Геннадьевич Тришкин +10 more
doaj