Results 1 to 10 of about 20,713 (213)

Noncatalytic Domains in DNA Glycosylases. [PDF]

Int J Mol Sci, 2022
Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory processes.
Torgasheva NA, Diatlova EA, Grin IR, Endutkin AV, Mechetin GV, Vokhtantsev IP, Yudkina AV, Zharkov DO.   +7 more
europepmc   +3 more sources

DNA glycosylases: in DNA repair and beyond [PDF]

Chromosoma, 2011
The base excision repair machinery protects DNA in cells from the damaging effects of oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form of small chemical modifications. Base modifications can be mutagenic and/
A Banerjee, A Bellacosa, A Hermann, A Klungland, A Maiti, A Maiti, AB Robertson, AK Boal, AM Sheehy, Angelika L. Jacobs, B Hang, B Hendrich, B Karahalil, B Kavli, B Kavli, B Loon van, B Schrofelbauer, B Schrofelbauer, B Sun, B Yang, B Zhu, B Zhu, B Zhu, BP Engelward, C Dherin, C Kunz, C Kunz, C Popp, C Rada, C Rada, CA Miller, CB Millar, CD Mol, CF Kuo, CY Lee, D Baba, D Bruniquel, D Cortazar, D Cortazar, D Frieder, D Thomas, DK Ma, DO Zharkov, DR Denver, E Wong, EC Friedberg, EH Radany, F Petronzelli, G Slupphaug, H Dou, H Nilsen, H Nilsen, H Nilsen, HE Krokan, HM Nash, HM Nash, I Morland, J Janik, J Noia Di, J Oswald, J Penterman, JB Parker, JC Fromme, JE Wibley, JI Friedman, JI Friedman, JK Zhu, JM Noia Di, JP Horst, JP Jost, JP Jost, JP McGoldrick, JP Radicella, JW Hill, K Imai, K Rai, K Torisu, KA Haushalter, KG Au, KH Almeida, L Eide, L Hagen, LB Meira, LM Iyer, M Dizdaroglu, M Liu, M Monk, M Muramatsu, M Otterlei, M Radman, M Stanczyk, M Tahiliani, M Takao, M Tini, M Wiesendanger, MA Pope, MS Kim, MT Ocampo, MT Russo, N Al-Tassan, N Bhutani, NA Begum, NA Begum, OG Berg, P Borst, P Gallinari, P Neddermann, PA Kemp van der, PC Blainey, PD Bardwell, PO Falnes, Primo Schär, Q An, Q An, R Lister, R Lu, R Metivier, R Pavri, R Savva, R Steinacher, RJ Boorstein, RJ Melamede, RK Holmes, RP Cunningham, RS Harris, S Cortellino, S Cortellino, S Ito, S Jones, S Kangaspeska, S Schanz, S Schwarz, S Simonsson, S Um, S Wirtz, SC Trewick, SD Bruner, SG Conticello, SH Wilson, SL Porello, SS Parikh, SS Parikh, SV Cannon, SV Cannon-Carlson, T Kafri, T Lindahl, T Lindahl, TA Rosenquist, TE Barrett, TE Barrett, TJ Begley, TK Hazra, TM Wilson, TR O'Connor, TR O'Connor, TR Waters, TR Waters, U Hardeland, U Hardeland, U Hardeland, U Hardeland, V Rusmintratip, V Valinluck, V Vartanian, W Dean, W Mayer, Y Guan, Y Shimizu   +167 more
core   +10 more sources

Inhibitors of DNA Glycosylases as Prospective Drugs. [PDF]

Int J Mol Sci, 2020
DNA glycosylases are enzymes that initiate the base excision repair pathway, a major biochemical process that protects the genomes of all living organisms from intrinsically and environmentally inflicted damage. Recently, base excision repair inhibition proved to be a viable strategy for the therapy of tumors that have lost alternative repair pathways,
Mechetin GV, Endutkin AV, Diatlova EA, Zharkov DO.   +3 more
europepmc   +5 more sources

Poxvirus uracil-DNA glycosylase-An unusual member of the family I uracil-DNA glycosylases. [PDF]

Protein Sci, 2016
AbstractUracil‐DNA glycosylases are ubiquitous enzymes, which play a key role repairing damages in DNA and in maintaining genomic integrity by catalyzing the first step in the base excision repair pathway. Within the superfamily of uracil‐DNA glycosylases family I enzymes or UNGs are specific for recognizing and removing uracil from DNA.
Schormann N, Zhukovskaya N, Bedwell G, Nuth M, Gillilan R, Prevelige PE, Ricciardi RP, Banerjee S, Chattopadhyay D.   +8 more
europepmc   +5 more sources

The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure. [PDF]

Sci Rep, 2017
Interstrand cross-links (ICLs) are highly cytotoxic DNA lesions that block DNA replication and transcription by preventing strand separation. Previously, we demonstrated that the bacterial and human DNA glycosylases Nei and NEIL1 excise unhooked ...
Martin PR, Couvé S, Zutterling C, Albelazi MS, Groisman R, Groisman R, Matkarimov BT, Parsons JL, Elder RH, Saparbaev MK.   +9 more
europepmc   +5 more sources

Computational and Experimental Druggability Assessment of Human DNA Glycosylases. [PDF]

ACS Omega, 2019
Due to a polar or even charged binding interface, DNA-binding proteins are considered extraordinarily difficult targets for development of small-molecule ligands and only a handful of proteins have been targeted successfully to date.
Michel M, Visnes T, Homan EJ, Seashore-Ludlow B, Hedenström M, Wiita E, Vallin K, Paulin CBJ, Zhang J, Wallner O, Scobie M, Schmidt A, Jenmalm-Jensen A, Warpman Berglund U, Helleday T.   +14 more
europepmc   +4 more sources

DNA glycosylases search for and remove oxidized DNA bases. [PDF]

Environ Mol Mutagen, 2013
This review article presents, an overview of the DNA glycosylases that recognize oxidized DNA bases using the Fpg/Nei family of DNA glycosylases as models for how structure can inform function. For example, even though human NEIL1 and the plant and fungal orthologs lack the zinc finger shown to be required for binding, DNA crystal structures revealed a
Wallace SS.
europepmc   +5 more sources

Functional characterization of 8-oxoguanine DNA glycosylase of Trypanosoma cruzi [PDF]

, 2012
The oxidative lesion 8-oxoguanine (8-oxoG) is removed during base excision repair by the 8-oxoguanine DNA glycosylase 1 (Ogg1). This lesion can erroneously pair with adenine, and the excision of this damaged base by Ogg1 enables the insertion of a ...
Campos, PC, de Moura, MB, Franco, GR, Furtado, C, Kunrath-Lima, M, Macedo, AM, Machado, CR, Mendes, IC, Pena, SDJ, Rajão, MA, Teixeira, SMR, van Houten, B   +11 more
core   +12 more sources

DNA Nanotechnology Meets Nanophotonics [PDF]

Nano Lett. 20 8430 (2020), 2021
In the past decades, DNA has been intensely studied and exploited in different research areas of nanoscience and nanotechnology. At first glance, DNA-based nanophotonics seems to deviate quite far from the original goal of Nadrian Seeman, the founder of DNA nanotechnology, who hoped to organize biological entities using DNA in high-resolution crystals.
arxiv   +1 more source

DNA glycosylases in the base excision repair of DNA [PDF]

Biochemical Journal, 1997
A wide range of cytotoxic and mutagenic DNA bases are removed by different DNA glycosylases, which initiate the base excision repair pathway. DNA glycosylases cleave the N-glycosylic bond between the target base and deoxyribose, thus releasing a free base and leaving an apurinic/apyrimidinic (AP) site.
Geir Slupphaug, Rune Standal, Hans E. Krokan   +2 more
openaire   +3 more sources