Geminiviruses employ host DNA glycosylases to subvert DNA methylation-mediated defense [PDF]
Nature Communications, 2022 Plants tightly regulate DNA methylation to regulate gene expression. Here, the authors show that the tomato yellow leaf curl China virus βC1 protein interacts with plant DNA glycosylases to promote demethylation of viral DNA and promote virulence.
Xiaojian Gui +3 more
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NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice [PDF]
Communications Biology, 2021 Gunn Hildrestrand, Veslemøy Rolseth, and Nicolas Kunath et al. examine mice lacking the NEIL1 and NEIL2 DNA glycosylases involved in base excision repair.
Gunn A. Hildrestrand +23 more
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NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress [PDF]
eLife, 2019 Base excision repair (BER) functions not only in the maintenance of genomic integrity but also in active DNA demethylation and epigenetic gene regulation.
Dandan Han +8 more
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No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice [PDF]
Scientific Reports, 2017 Base excision repair (BER) is a major pathway for removal of DNA base lesions and maintenance of genomic stability, which is essential in cancer prevention. DNA glycosylases recognize and remove specific lesions in the first step of BER. The existence of
Veslemøy Rolseth +14 more
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Computational and Experimental Druggability Assessment of Human DNA Glycosylases [PDF]
ACS Omega, 2019 Due to a polar or even charged binding interface, DNA-binding proteins are considered extraordinarily difficult targets for development of small-molecule ligands and only a handful of proteins have been targeted successfully to date.
Maurice Michel +14 more
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Poxvirus uracil-DNA glycosylase-An unusual member of the family I uracil-DNA glycosylases. [PDF]
Protein Sci, 2016 AbstractUracil‐DNA glycosylases are ubiquitous enzymes, which play a key role repairing damages in DNA and in maintaining genomic integrity by catalyzing the first step in the base excision repair pathway. Within the superfamily of uracil‐DNA glycosylases family I enzymes or UNGs are specific for recognizing and removing uracil from DNA.
Schormann N +8 more
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In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities. [PDF]
Proc Natl Acad Sci U S A, 2017 Chaim IA +5 more
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Inhibitors of DNA Glycosylases as Prospective Drugs. [PDF]
Int J Mol Sci, 2020 DNA glycosylases are enzymes that initiate the base excision repair pathway, a major biochemical process that protects the genomes of all living organisms from intrinsically and environmentally inflicted damage.
Mechetin GV +3 more
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Noncatalytic Domains in DNA Glycosylases. [PDF]
Int J Mol Sci, 2022 Many proteins consist of two or more structural domains: separate parts that have a defined structure and function. For example, in enzymes, the catalytic activity is often localized in a core fragment, while other domains or disordered parts of the same protein participate in a number of regulatory processes.
Torgasheva NA +7 more
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Distinct Mechanisms of Target Search by Endonuclease VIII-like DNA Glycosylases [PDF]
Cells, 2022 Proteins that recognize specific DNA sequences or structural elements often find their cognate DNA lesions in a processive mode, in which an enzyme binds DNA non-specifically and then slides along the DNA contour by one-dimensional diffusion. Opposite to
Evgeniia A. Diatlova +2 more
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