Results 101 to 110 of about 20,880 (290)

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of colorectal cancer, 2024 update

Cancer Communications, Volume 45, Issue 3, Page 332-379, March 2025.
Abstract The 2024 updates of the Chinese Society of Clinical Oncology (CSCO) Clinical Guidelines for the diagnosis and treatment of colorectal cancer emphasize standardizing cancer treatment in China, highlighting the latest advancements in evidence‐based medicine, healthcare resource access, and precision medicine in oncology.
Feng Wang, Gong Chen, Zhen Zhang, Ying Yuan, Yi Wang, Yuan‐Hong Gao, Weiqi Sheng, Zixian Wang, Xinxiang Li, Xianglin Yuan, Sanjun Cai, Li Ren, Yunpeng Liu, Jianmin Xu, Yanqiao Zhang, Houjie Liang, Xicheng Wang, Aiping Zhou, Jianming Ying, Guichao Li, Muyan Cai, Gang Ji, Taiyuan Li, Jingyu Wang, Hanguang Hu, Kejun Nan, Liuhong Wang, Suzhan Zhang, Jin Li, Rui‐Hua Xu   +29 more
wiley   +1 more source

Life without dUTPase [PDF]

arXiv, 2015
Fine-tuned regulation of the cellular nucleotide pools is indispensable for faithful replication of DNA. The genetic information is also safeguarded by DNA damage recognition and repair processes. Uracil is one of the most frequently occurring erroneous base in DNA; it can arise from cytosine deamination or thymine-replacing incorporation.
arxiv  

Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases [PDF]

, 2017
Oxidative damage represents a major threat to genomic stability, as the major product of DNA oxidation, 8-oxoguanine (GO), frequently mispairs with adenine during replication.
Hunziker, P., Jiricny, J., Lingaraju, G M., Sartori, A A., Winkler, F K.   +4 more
core  

DNA repair glycosylases with a [4Fe–4S] cluster: A redox cofactor for DNA-mediated charge transport? [PDF]

, 2007
The [4Fe–4S] cluster is ubiquitous to a class of base excision repair enzymes in organisms ranging from bacteria to man and was first considered as a structural element, owing to its redox stability under physiological conditions.
Barton, Jacqueline K., Boal, Amie K., Yavin, Eylon   +2 more
core   +1 more source

Hydroxymethyluracil DNA glycosylase in mammalian cells. [PDF]

Proceedings of the National Academy of Sciences, 1984
An activity has been purified 350-fold from extracts of mouse plasmacytoma cells that forms 5-hydroxymethyluracil (alpha-hydroxythymine) and apyrimidinic sites with phage SPO1 DNA, which contains this base in place of thymine. This DNA glycosylase presumably functions to eliminate hydroxymethyluracil, a major thymine-derived DNA lesion produced by ...
Monica Hollstein, Bruce N. Ames, Stuart Linn, Peter Brooks   +3 more
openaire   +2 more sources

Orchestrated desaturation reprogramming from stearoyl‐CoA desaturase to fatty acid desaturase 2 in cancer epithelial‐mesenchymal transition and metastasis

Cancer Communications, Volume 45, Issue 3, Page 245-280, March 2025.
Abstract Background Adaptative desaturation in fatty acid (FA) is an emerging hallmark of cancer metabolic plasticity. Desaturases such as stearoyl‐CoA desaturase (SCD) and fatty acid desaturase 2 (FADS2) have been implicated in multiple cancers, and their dominant and compensatory effects have recently been highlighted.
Zhicong Chen, Yanqing Gong, Fukai Chen, Hyeon Jeong Lee, Jinqin Qian, Jing Zhao, Wenpeng Zhang, Yamin Li, Yihui Zhou, Qiaobing Xu, Yu Xia, Liqun Zhou, Ji‐Xin Cheng   +12 more
wiley   +1 more source

Monte Carlo simulation of melting transition on DNA nanocompartment [PDF]

, 2005
DNA nanocompartment is a typical DNA-based machine whose function is dependent of molecular collective effect. Fundamental properties of the device have been addressed via electrochemical analysis, fluorescent microscopy, and atomic force microscopy. Interesting and novel phenomena emerged during the switching of the device.
arxiv   +1 more source

Uracil in DNA and its processing by different DNA glycosylases [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2008
Uracil in DNA may result from incorporation of dUMP during replication and from spontaneous or enzymatic deamination of cytosine, resulting in U:A pairs or U:G mismatches, respectively. Uracil generated by activation-induced cytosine deaminase (AID) in B cells is a normal intermediate in adaptive immunity.
Bodil Kavli, Lars Hagen, Mansour Akbari, Marit Otterlei, Geir Slupphaug, Berit Doseth, Mirta M. L. Sousa, Torkild Visnes, Henrik Sahlin Pettersen, Hans E. Krokan   +9 more
openaire   +3 more sources

Mitochondria‐Targeted Temozolomide Probe for Overcoming MGMT‐Mediated Resistance in Glioblastoma

ChemBioChem, Volume 26, Issue 6, March 15, 2025.
Mitochondria‐targeted temozolomide (mtTmz) using peptide‐based delivery vector has been shown to overcome direct DNA repair and resistance by O6‐methylgunaine DNA methyltransferase (MGMT) in glioblastoma (GBM) cells. This has been demonstrated through viability assays using MGMT‐positive and negative cell lines, and the effect of mtTmz on MGMT ...
Daniel Szames, Shana O. Kelley
wiley   +1 more source

DNA-based Artificial Nanostructures: Fabrication, Properties, and Applications [PDF]

arXiv, 2005
Table of Content 1. Introduction 2. DNA fundamentals 3. Attachment of DNA to surface 4. Fabrication of nanostructures using DNA 4.1 Nanostructures of pure DNA 4.2 DNA-based assembly of metal nanoparticles 4.3 Construction of semiconductor particle arrays using DNA 4.4 DNA-directed nanowires 4.5 DNA-functionalized carbon nanotubes 4 ...
arxiv