Results 31 to 40 of about 20,880 (290)

Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases. [PDF]

, 2015
MutY adenine glycosylases prevent DNA mutations by excising adenine from promutagenic 8-oxo-7,8-dihydroguanine (OG):A mismatches. Here, we describe structural features of the MutY active site bound to an azaribose transition state analog which indicate a
Cao, Sheng, Chu, Aurea, David, Sheila S, Horvath, Martin P, O'Shea, Valerie L, Richards, Jody L, Woods, Ryan D   +6 more
core   +2 more sources

DNA Sequence Context Effects on the Glycosylase Activity of Human 8-Oxoguanine DNA Glycosylase [PDF]

Journal of Biological Chemistry, 2012
Human 8-oxoguanine DNA glycosylase (OGG1) is a key enzyme involved in removing 7,8-dihydro-8-oxoguanine (8-oxoG), a highly mutagenic DNA lesion generated by oxidative stress. The removal of 8-oxoG by OGG1 is affected by the local DNA sequence, and this feature most likely contributes to observed mutational hot spots in genomic DNA.
William A. Beard, Rajendra Prasad, Akira Sassa, Samuel H. Wilson   +3 more
openaire   +3 more sources

Emergence of highly profibrotic and proinflammatory Lrat+Fbln2+ HSC subpopulation in alcoholic hepatitis

Hepatology, EarlyView., 2022
Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog, Reika Fujiwara, Stephanie Q. Pan, Khairat B. El‐Baradie, Hye Yeon Choi, Sonal Sinha, Qihong Yang, Kinji Asahina, Yibu Chen, Meng Li, Matthew Salomon, Stanley W.‐K. Ng, Hidekazu Tsukamoto   +12 more
wiley   +1 more source

A Novel 3-Methyladenine DNA Glycosylase from Helicobacter pylori Defines a New Class within the Endonuclease III Family of Base Excision Repair Glycosylases [PDF]

, 2000
The cloning, purification, and characterization of MagIII, a 3-methyladenine DNA glycosylase from Helicobacter pylori, is presented in this paper. Sequence analysis of the genome of this pathogen failed to identify open reading frames potentially coding ...
Boiteux, Serge, Chevalier, Catherine, Ielpi, Luis, Labigne, Agnès, O'Rourke, Eyleen J., Radicella, Juan Pablo   +5 more
core   +1 more source

Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases [PDF]

DNA Repair, 2009
Formamidopyrimidine DNA glycosylase (Fpg) and endonuclease VIII (Nei) share an overall common three-dimensional structure and primary amino acid sequence in conserved structural motifs but have different substrate specificities, with bacterial Fpg proteins recognizing formamidopyrimidines, 8-oxoguanine (8-oxoG) and its oxidation products ...
Michael R. Newton, Viswanath Bandaru, Jeffrey P. Bond, Miral Dizdaroglu, Susan S. Wallace, Cynthia J. Burrows, Ramiro Barrantes-Reynolds, Pawel Jaruga, Scott D. Kathe   +8 more
openaire   +3 more sources

The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway [PDF]

, 2004
In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a DNA glycosylase-independent manner, providing the correct ends for DNA synthesis coupled to the repair of the remaining 5'-dangling modified nucleotide.
Elder, RH, Gros, L, Ide, H, Ishchenko, AA, Saparbaev, MK   +4 more
core   +5 more sources

Oxanine DNA Glycosylase Activity from Mammalian Alkyladenine Glycosylase [PDF]

Journal of Biological Chemistry, 2004
Oxanine (Oxa) is a deaminated base lesion derived from guanine in which the N(1)-nitrogen is substituted by oxygen. This work reports the mutagenicity of oxanine as well as oxanine DNA glycosylase (ODG) activities in mammalian systems. Using human DNA polymerase beta, deoxyoxanosine triphosphate is only incorporated opposite cytosine (Cyt).
Hitchcock, TM, Dong, L, Connor, EE, Meira, LB, Samson, LD, Wyatt, MD, Cao, WG   +6 more
openaire   +4 more sources

Synergistic Actions of Ogg1 and Mutyh DNA Glycosylases Modulate Anxiety-like Behavior in Mice

Cell Reports, 2015
Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases.
Monica D. Bjørge, Gunn A. Hildrestrand, Katja Scheffler, Rajikala Suganthan, Veslemøy Rolseth, Anna Kuśnierczyk, Alexander D. Rowe, Cathrine B. Vågbø, Susanne Vetlesen, Lars Eide, Geir Slupphaug, Yusaku Nakabeppu, Timothy W. Bredy, Arne Klungland, Magnar Bjørås   +14 more
doaj   +1 more source

The interplay of mutations and electronic properties in disease-related genes [PDF]

Scientific Reports 2, 272-9 (2012), 2011
Electronic properties of DNA are believed to play a crucial role in many phenomena in living organisms, for example the location of DNA lesions by base excision repair (BER) glycosylases and the regulation of tumor-suppressor genes such as p53 by detection of oxidative damage.
arxiv   +1 more source

Impact of self-association on the architectural properties of bacterial nucleoid proteins [PDF]

Biophysical Journal, 120 (2021) 370-378, 2021
The chromosomal DNA of bacteria is folded into a compact body called the nucleoid, which is composed essentially of DNA (80%), RNA (10%), and a number of different proteins (10%). These nucleoid proteins act as regulators of gene expression and influence the organization of the nucleoid by bridging, bending, or wrapping the DNA.
arxiv   +1 more source