Results 31 to 40 of about 2,038,987 (238)
Nature Communications, 2021 Microbial DNA glycosylases associated with the biosynthesis of DNA-damaging antibiotics have evolved self-resistance for their cognate natural products.
Elwood A. Mullins +4 more
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A New Family of HEAT-Like Repeat Proteins Lacking a Critical Substrate Recognition Motif Present in Related DNA Glycosylases. [PDF]
PLoS ONE, 2015 DNA glycosylases are important repair enzymes that eliminate a diverse array of aberrant nucleobases from the genomes of all organisms. Individual bacterial species often contain multiple paralogs of a particular glycosylase, yet the molecular and ...
Elwood A Mullins +3 more
doaj +1 more source
DNA glycosylases search for and remove oxidized DNA bases. [PDF]
Environ Mol Mutagen, 2013 Wallace SS.
europepmc +2 more sources
Hepatology, EarlyView., 2022 Lrat+ quiescent hepatic stellate cells (qHSC) give rise to Lrat+Fbln2+ activated HSC (aHSC) in alcohol‐associated hepatitis and this subpopulation is highly profibrotic, inflammatory, and immunoregulatory based on their single cell transcriptomic profile. Abstract Background and Aims Relative roles of HSCs and portal fibroblasts in alcoholic hepatitis (
Steven Balog +12 more
wiley +1 more source
Open Biology, 2021 Base excision repair is one of the important DNA repair mechanisms in cells. The fundamental role in this complex process is played by DNA glycosylases.
Anna Ligasová +4 more
doaj +1 more source
DNA glycosylases: in DNA repair and beyond [PDF]
Chromosoma, 2011 The base excision repair machinery protects DNA in cells from the damaging effects of oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form of small chemical modifications. Base modifications can be mutagenic and/or cytotoxic, depending on how they interfere with the template function of the DNA during ...
Jacobs, A. L., Schar, P.
openaire +6 more sources
Oxanine DNA Glycosylase Activity from Mammalian Alkyladenine Glycosylase [PDF]
Journal of Biological Chemistry, 2004 Oxanine (Oxa) is a deaminated base lesion derived from guanine in which the N(1)-nitrogen is substituted by oxygen. This work reports the mutagenicity of oxanine as well as oxanine DNA glycosylase (ODG) activities in mammalian systems. Using human DNA polymerase beta, deoxyoxanosine triphosphate is only incorporated opposite cytosine (Cyt).
Hitchcock, TM +6 more
openaire +3 more sources
Nature Communications, 2021 Active DNA demethylation is required for sexual reproduction in plants, but the underlying mechanisms are unknown. Here, the authors show that the DNA glycosylases DEMETER and REPRESSOR OF SILENCING 1 enable the DNA demethylation-dependent activation of ...
Souraya Khouider +7 more
doaj +1 more source
The lyase activity of bifunctional DNA glycosylases and the 3'-diesterase activity of APE1 contribute to the repair of oxidized bases in nucleosomes. [PDF]
Nucleic Acids Res, 2019 Maher RL, Wallace SS, Pederson DS.
europepmc +3 more sources
Non-flipping DNA glycosylase AlkD scans DNA without formation of a stable interrogation complex
Communications Biology, 2021 Ahmadi et al. use a single-molecule tracking method to describe the DNA scanning mode of AlkD, a HEAT-like repeat DNA glycosylase. They show that, contrary to other glycosylases that use a base-flipping mechanism, AlkD scans the DNA without forming a ...
Arash Ahmadi +10 more
doaj +1 more source