Results 61 to 70 of about 20,880 (290)
Kinetics of the Action of Thymine DNA Glycosylase [PDF]
Journal of Biological Chemistry, 1998 The time course of removal of thymine by thymine DNA glycosylase has been measured in vitro. Each molecule of thymine DNA glycosylase removes only one molecule of thymine from DNA containing a G.T mismatch because it binds tightly to the apurinic DNA site left after removal of thymine.
Timothy R. Waters, Peter F. Swann
openaire +2 more sources
Epigenetics, 2017 DNA methylation is a crucial epigenetic mark associated to gene silencing, and its targeted removal is a major goal of epigenetic editing. In animal cells, DNA demethylation involves iterative 5mC oxidation by TET enzymes followed by replication ...
Jara Teresa Parrilla-Doblas +2 more
doaj +1 more source
Expression patterns of
BMC Neuroscience, 2009 Background The base excision repair pathway is responsible for repairing small DNA base lesions caused by endogenous and exogenous damaging agents. Repair is initiated by DNA glycosylases that recognize and remove the lesions.
Bjørås Magnar +6 more
doaj +1 more source
DNA repair: How yeast repairs radical damage [PDF]
, 1996 Cloning of the OGG1 gene from Saccharomyces cerevisiae has revealed that DNA glycosylases are not necessarily conserved throughout phylogeny, yet there is a DNA-repair protein superfamily with a wide substrate specificity found from bacteria to ...
Cunningham, Richard P.
core +1 more source
DNA repair and disease: insights from the human DNA glycosylase NEIL family. [PDF]
Exp Mol MedThe base excision repair pathway protects DNA from base damage via oxidation, deamination, alkylation and methylation. DNA glycosylases are key enzymes that recognize damaged bases in a lesion-specific manner and initiate the base excision repair process.
Hwang Y +5 more
europepmc +2 more sources
Base excision repair deficient mice lacking the Aag alkyladenine DNA glycosylase. [PDF]
, 1997 3-methyladenine (3MeA) DNA glycosylases remove 3MeAs from alkylated DNA to initiate the base excision repair pathway. Here we report the generation of mice deficient in the 3MeA DNA glycosylase encoded by the Aag (Mpg) gene.
Allan, J.M. (James) +9 more
core +3 more sources
Elongation/Compaction of Giant DNA Caused by Depletion Interaction with a Flexible Polymer [PDF]
, 2005 Structural changes in giant DNA induced by the addition of the flexible polymer PEG were examined by the method of single-DNA observation. In dilute DNA conditions, individual DNA assumes a compact state via a discrete coil-globule transition, whereas in concentrated solution, DNA molecules exhibit an extended conformation via macroscopic phase ...
arxiv +1 more source
Advanced Sensor Research, EarlyView.A novel approach for direct sensing of viral RNA is proposed, allowing PCR‐free detection of viral RNA from genomic material, and variants screening by discrimination of polymorphic amplicons. The device is a cost‐effective, user‐friendly platform suitable for both mass screening kits and as a laboratory tool for an optimized management of resources ...
Stefano Lai +4 more
wiley +1 more source
Chemical Biology of Mammalian DNA Repair
CHIMIA, 2001 Damage to the heterocyclic bases of DNA in the genome is mainly corrected by the base excision repair (BER) or nucleotide excision repair (NER) pathways.
Orlando D. Schärer
doaj +2 more sources
Mechanisms of base selection by the E.coli mispaired uracil glycosylase [PDF]
, 2008 The repair of the multitude of single-base lesions formed daily in the cells of all living organisms is accomplished primarily by the base-excision repair (BER) pathway that initiates repair through a series of lesion-selective glycosylases.
Darwanto, Agus +6 more
core +2 more sources