Results 51 to 60 of about 38,912 (254)

Comprehensive Insights into Natural Bioactive Compounds: From Chemical Diversity and Mechanisms to Biotechnological Innovations and Applications

ChemistryOpen, EarlyView.
Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali, Atif Ali Khan Khalil, Muhammad Saeed Akhtar, Adnan Amin, Wajid Zaman   +4 more
wiley   +1 more source

Green Synthesis of ZnO Nanoparticles From Spirulina platensis: Antimicrobial and Cytotoxic Evaluation With Molecular Docking Studies

ChemistryOpen, EarlyView.
Algal‐extract‐derived ZnO nanoparticles show shape anisotropy and are bio capped by phytochemicals. These green‐synthesized NPs strongly inhibit S. aureus and K. pneumoniae biofilms. Molecular docking suggests stable binding of surface biomolecules to microbial targets, highlighting synergistic antibacterial mechanisms.
Muhammad Rizwan, Izaz Khan, Syed Sikandar Shah, Amir hamza khan, Abdurahman Hajinur Hirad, Saira Naz, Arshad Farid, Taimoor Khan, Said Hassan   +8 more
wiley   +1 more source

Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development

European Journal of Medicinal Chemistry Reports
DNA gyrase is a member of the DNA topoisomerase protein family that catalyzes the conversion of different topological forms of DNA into one another. It is the sole enzyme that causes DNA to negatively supercoil. The enzyme is tetrameric with two GyrA (“A'
K. Rajakumari, K. Aravind, M. Balamugundhan, Manjunathan Jagadeesan, Ambiga Somasundaram, Parthiban Brindha Devi, Pasiyappazham Ramasamy   +6 more
doaj   +1 more source

Transformation of a Thermostable G-Quadruplex Structure into DNA Duplex Driven by Reverse Gyrase

Molecules, 2017
Reverse gyrase is a topoisomerase that can introduce positive supercoils to its substrate DNA. It is demonstrated in our studies that a highly thermal stable G-quadruplex structure in a mini-plasmid DNA was transformed into its duplex conformation after ...
Dawei Li, Qiang Wang, Yun Liu, Kun Liu, Qiang Zhuge, Bei Lv   +5 more
doaj   +1 more source

Prophage Gifsy-1 Induction in Salmonella enterica Serovar Typhimurium Reduces Persister Cell Formation after Ciprofloxacin Exposure

Microbiology Spectrum, 2023
Persister cells are drug-tolerant bacteria capable of surviving antibiotic treatment despite the absence of heritable resistance mechanisms. It is generally thought that persister cells survive antibiotic exposure through the implementation of stress ...
Sebastian Braetz, Peter Schwerk, Nara Figueroa-Bossi, Karsten Tedin, Marcus Fulde   +4 more
doaj   +1 more source

The Transcriptome of Streptococcus pneumoniae Induced by Local and Global Changes in Supercoiling [PDF]

, 2017
The bacterial chromosome is compacted in a manner optimal for DNA transactions to occur. The degree of compaction results from the level of DNA-supercoiling and the presence of nucleoid-binding proteins.
Adela G. de la Campa, Adela G. de la Campa, Antonio J. Martín-Galiano, Jose M. Tirado-Vélez, María J. Ferrándiz, María T. García   +5 more
core   +5 more sources

Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling. [PDF]

, 2020
The CRISPR-Cas9 nuclease has been widely repurposed as a molecular and cell biology tool for its ability to programmably target and cleave DNA. Cas9 recognizes its target site by unwinding the DNA double helix and hybridizing a 20-nucleotide section of ...
Aris, Kevin D Palacio, Bryant, Zev, Cofsky, Joshua C, Doudna, Jennifer A, Ivanov, Ivan E, Wright, Addison V   +5 more
core   +3 more sources

Potential of bacteria isolated from chitin‐enriched soil against Euschistus heros (Hemiptera: Pentatomidae)

Pest Management Science, EarlyView.
B. thuringiensis and B. altitudinis, isolated from chitin‐enriched soil, causing mortality in Euchistus heros under laboratory conditions. First report of B. altitudinis in the control of E. heros. Abstract BACKGROUND Biological control using entomopathogenic microorganisms is a more sustainable alternative to chemical pesticides for managing insect ...
Vicente Guilherme Handte, Valéria Ortaça Portela, Nariane de Andrade, Valdemir Bittencourt Soares, Andressa de Souza Pollo, Ricardo Antonio Polanczyk, Rodrigo Josemar Seminoti Jacques   +6 more
wiley   +1 more source

Structural analysis of the NifL‐NifA complex reveals the molecular basis of anti‐activation of nitrogen fixation gene expression in Azotobacter vinelandii

The FEBS Journal, EarlyView.
Using cryo‐EM combined with biochemical and genetic approaches, we mapped the interaction surface between NifL and NifA to gain insights into the regulation of nitrogen fixation genes in A. vinelandii. Our findings suggest that NifL, a homolog of histidine kinases lacking phosphorylation activity, evolved to act as a steric block of NifA activity ...
Marcelo Bueno Batista, Jake Richardson, Michael W. Webster, Dmitry Ghilarov, John W. Peters, David M. Lawson, Ray Dixon   +6 more
wiley   +1 more source

Identification of New Drug Candidates Against \u3cem\u3eBorrelia burgdorferi\u3c/em\u3e Using High-Throughput Screening [PDF]

, 2016
Lyme disease is the most common zoonotic bacterial disease in North America. It is estimated that .300,000 cases per annum are reported in USA alone. A total of 10%–20% of patients who have been treated with antibiotic therapy report the recrudescence of
Babar, Mustafeez Mujtaba, Inayathullah, Mohammed, Kim, K. M., Parekh, Mansi B., Pothineni, Venkata Raveendra, Rajadas, Jayakumar, Samineni, A. V., Solow-Cordero, David, Tayebi, Lobat, Wagh, Dhananjay   +9 more
core   +3 more sources