Results 81 to 90 of about 38,912 (254)
Characterization of the Interaction between DNA Gyrase Inhibitor and DNA Gyrase of Escherichia coli [PDF]
Journal of Biological Chemistry, 2002 Escherichia coli DNA gyrase is comprised of two subunits, GyrA and GyrB. Previous studies have shown that GyrI, a regulatory factor of DNA gyrase activity, inhibits the supercoiling activity of DNA gyrase and that both overexpression and antisense expression of the gyrI gene suppress cell proliferation.
Akira, Nakanishi +2 more
openaire +2 more sources
Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.This pharmacovigilance study identifies a wide range of rapid‐onset neuropsychiatric and ocular adverse effects linked to fluoroquinolones (FQ). Disproportionality analysis revealed a disproportionate reporting of suicidal ideation and visual impairment following FQ treatment, emphasizing the urgent need for cautious prescribing and strengthened safety
Hau‐Tak Chau, Ngan Pan Bennett Au
wiley +1 more source
Scientific Reports, 2022 Tuberculosis is a disease that remains a significant threat to public health worldwide, and this is mainly due to the selection of strains increasingly resistant to Mycobacterium tuberculosis, its causative agent.
Juan Marcelo Carpio Arévalo +1 more
doaj +1 more source
The MarR-Type Repressor MhqR Confers Quinone and Antimicrobial Resistance in Staphylococcus aureus [PDF]
, 2019 Aims: Quinone compounds are electron carriers and have antimicrobial and toxic properties due to their mode of actions as electrophiles and oxidants.
Fritsch, Verena Nadin +9 more
core +1 more source
Novel compounds targeting bacterial DNA topoisomerase/DNA gyrase
Current Opinion in Pharmacology, 2014 Among the targets for the development of new antibacterial agents, bacterial topoisomerases remain a vibrant area of discovery. A structurally diverse set of inhibitors that bind to the adenosine 5'-triphosphate (ATP) site of type II topoisomerases have been disclosed recently.
Ehmann, David E, Lahiri, Sushmita D.
openaire +2 more sources
Clinical and Translational Science, Volume 19, Issue 2, February 2026.ABSTRACT Nontuberculous mycobacteria (NTM) are emerging global pathogens. This study aimed to analyze the clinical features, species distribution, and drug resistance profiles of NTM infections in a northern Chinese hospital. A retrospective cohort study included 1769 patients with suspected mycobacterial infection from August 2023 to July 2025.
Kedi Wang +4 more
wiley +1 more source
Supercoiling Effects on Short-Range DNA Looping in E. coli. [PDF]
PLoS ONE, 2016 DNA-protein loops can be essential for gene regulation. The Escherichia coli lactose (lac) operon is controlled by DNA-protein loops that have been studied for decades.
Lauren S Mogil +2 more
doaj +1 more source
Archiv der Pharmazie, Volume 359, Issue 1, January 2026.Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová +9 more
wiley +1 more source
Docking studies on novel analogs of quinolones against DNA gyrase of Escherichia coli [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2018 Context: Bacterial resistance to antibiotics is the inevitable consequence of the use of antimicrobial agents. Thus, quinolones are an important class of antibacterials; these agents generally consist of a 1-subtituted-1,4-dihydro-4-oxopyridine-3 ...
Cristian Davila +3 more
doaj
Benzothiazinone-piperazine derivatives as efficient Mycobacterium tuberculosis DNA gyrase inhibitors
International Journal of Mycobacteriology, 2015 Background and objectives: Bacterial DNA topoisomerases are unique in maintaining the DNA topology for cell viability. Mycobacterium tuberculosis (MTB) DNA gyrase, a sole type II topoisomerase has a larger scope as a target for developing novel ...
Manoj Chandran +6 more
doaj +1 more source