Results 41 to 50 of about 1,562,024 (293)

The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius [PDF]

, 2008
Background: The ubiquitous Rad50 and Mre11 proteins play a key role in many processes involved in the maintenance of genome integrity in Bacteria and Eucarya, but their function in the Archaea is presently unknown.
Patrick Forterre, Elie, Christiane, White, Malcolm F, White, Malcolm, Christiane Elie, Constantinesco, Florence, Quaiser, Achim, Forterre, Patrick, Achim Quaiser, Florence Constantinesco, Malcolm F White   +10 more
core   +1 more source

Protein Degradation Pathways Regulate the Functions of Helicases in the DNA Damage Response and Maintenance of Genomic Stability

Biomolecules, 2015
Degradation of helicases or helicase-like proteins, often mediated by ubiquitin-proteasomal pathways, plays important regulatory roles in cellular mechanisms that respond to DNA damage or replication stress.
Joshua A. Sommers, Avvaru N. Suhasini, Robert M. Brosh   +2 more
doaj   +1 more source

The molecular coupling between substrate recognition and ATP turnover in a AAA+ hexameric helicase loader

eLife, 2021
In many bacteria and eukaryotes, replication fork establishment requires the controlled loading of hexameric, ring-shaped helicases around DNA by AAA+(ATPases Associated with various cellular Activities) ATPases.
Neha Puri, Amy J Fernandez, Valerie L O'Shea Murray, Sarah McMillan, James L Keck, James M Berger   +5 more
doaj   +1 more source

Taking a molecular motor for a spin : helicase mechanism studied by spin labelling and PELDOR [PDF]

, 2015
Welcome Trust programme grant [WT091825MA to M.F.W., J.H.N.]; Wellcome Trust multi-user equipment grant [099149/Z/12/Z]. Royal Society Wolfseon Merit Award (to M.F.W., J.H.N.).
James H. Naismith, Naismith, Jim, Olav Schiemann, Petrovic-Stojanovska, Biljana, Constantinescu Aruxandei, Diana, Schiemann, Olav, Diana Constantinescu-arux, Malcolm F. White, White, Malcolm F, Biljana Petrovic-stojanovska   +9 more
core   +1 more source

Escherichia coli DNA repair helicase Lhr is also a uracil-DNA glycosylase [PDF]

, 2023
DNA glycosylases protect genetic fidelity during DNA replication by removing potentially mutagenic chemically damaged DNA bases. Bacterial Lhr proteins are well-characterized DNA repair helicases that are fused to additional 600–700 amino acids of ...
Lou‐Hing, Anna, Ahmed, Nadia R., Hanson, Karl M., Buckley, Ryan J., Christopher D. O. Cooper, Edward L. Bolt, Anna Lou‐Hing, Karl M. Hanson, Nadia R. Ahmed, Ryan J. Buckley, Lou-Hing, Anna, Cooper, Christopher D. O., Bolt, Edward L., Cooper, Christopher D.O.   +13 more
core   +1 more source

Localization of an accessory helicase at the replisome is critical in sustaining efficient genome duplication [PDF]

, 2010
© The Author(s) 2010. Published by Oxford University PressGenome duplication requires accessory helicases to displace proteins ahead of advancing replication forks.
Lloyd, RG, McGlynn, P, Hazel Bell, Robert G. Lloyd, John Atkinson, Peter McGlynn, Atkinson, J, Bell, H, Christian J. Rudolph, Gupta, MK, Rudolph, CJ, Milind K. Gupta   +11 more
core   +1 more source

Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome

Cell Reports, 2019
Summary: In the eukaryotic replisome, DNA unwinding by the Cdc45-MCM-Go-Ichi-Ni-San (GINS) (CMG) helicase requires a hexameric ring-shaped ATPase named minichromosome maintenance (MCM), which spools single-stranded DNA through its central channel.
Patrik Eickhoff, Hazal B. Kose, Fabrizio Martino, Tatjana Petojevic, Ferdos Abid Ali, Julia Locke, Nele Tamberg, Andrea Nans, James M. Berger, Michael R. Botchan, Hasan Yardimci, Alessandro Costa   +11 more
doaj   +1 more source

The Main Role of Srs2 in DNA Repair Depends on Its Helicase Activity, Rather than on Its Interactions with PCNA or Rad51

mBio, 2018
Homologous recombination (HR) is a mechanism that repairs a variety of DNA lesions. Under certain circumstances, however, HR can generate intermediates that can interfere with other cellular processes such as DNA transcription or replication.
Alex Bronstein, Lihi Gershon, Gilad Grinberg, Elisa Alonso-Perez, Martin Kupiec   +4 more
doaj   +1 more source

Splitting, joining and cutting : mechanistic studies of enzymes that manipulate DNA [PDF]

, 2010
Electronic version does not contain associated previously published materialDNA is a reactive and dynamic molecule that is continually damaged by both exogenous and endogenous agents.
McRobbie, Anne-Marie M.
core   +2 more sources

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

FEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda, Sreerama Chaitanya Sridhara, Aura Carreira   +2 more
wiley   +1 more source