Results 1 to 10 of about 2,162,763 (370)

The Sole DNA Ligase in Entamoeba histolytica Is a High-Fidelity DNA Ligase Involved in DNA Damage Repair [PDF]

Frontiers in Cellular and Infection Microbiology, 2018
The protozoan parasite Entamoeba histolytica is exposed to reactive oxygen and nitric oxide species that have the potential to damage its genome. E. histolytica harbors enzymes involved in DNA repair pathways like Base and Nucleotide Excision Repair. The
Elisa Azuara-Liceaga, Abigail Betanzos, Abigail Betanzos, Cesar S. Cardona-Felix, Cesar S. Cardona-Felix, Elizabeth J. Castañeda-Ortiz, Helios Cárdenas, Rosa E. Cárdenas-Guerra, Guillermo Pastor-Palacios, Guillermina García-Rivera, David Hernández-Álvarez, Carlos H. Trasviña-Arenas, Corina Diaz-Quezada, Esther Orozco, Luis G. Brieba   +14 more
doaj   +7 more sources

Identification of a novel motif in DNA ligases exemplified by DNA ligase IV [PDF]

DNA Repair, 2006
DNA ligase IV is an essential protein that functions in DNA non-homologous end-joining, the major mechanism that rejoins DNA double-strand breaks in mammalian cells. LIG4 syndrome represents a human disorder caused by mutations in DNA ligase IV that lead
Doherty, Aidan J, Jeggo, Penny, Marchetti, Caterina, Odreman, Federico, Vindigni, Alessandro, Walker, Sarah A   +5 more
core   +5 more sources

DNA ligase IV syndrome; a review [PDF]

Orphanet Journal of Rare Diseases, 2016
DNA ligase IV deficiency is a rare primary immunodeficiency, LIG4 syndrome, often associated with other systemic features. DNA ligase IV is part of the non-homologous end joining mechanism, required to repair DNA double stranded breaks. Ubiquitously expressed, it is required to prevent mutagenesis and apoptosis, which can result from DNA double strand ...
Thomas Altmann, Andrew R. Gennery, Andrew R. Gennery   +2 more
openaire   +4 more sources

DNA Ligase I, the Replicative DNA Ligase [PDF]

Sub-cellular biochemistry, 2012
Multiple DNA ligation events are required to join the Okazaki fragments generated during lagging strand DNA synthesis. In eukaryotes, this is primarily carried out by members of the DNA ligase I family. The C-terminal catalytic region of these enzymes is composed of three domains: a DNA binding domain, an adenylation domain and an OB-fold domain.
Timothy R.L. Howes, Alan E. Tomkinson
openaire   +4 more sources

XRCC1 Polypeptide Interacts with DNA Polymerase and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular 'Nick-Sensor' In Vitro [PDF]

Nucleic Acids Research, 1996
The DNA repair proteins XRCC1 and DNA ligase III are physically associated in human cells and directly interact in vitro and in vivo. Here, we demonstrate that XRCC1 is additionally associated with DNA polymerase-beta in human cells and that these ...
Keith W. Caldecott, Saïd Aoufouchi, Peter Johnson, Sidney SHALL   +3 more
openalex   +2 more sources

DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair.

PLoS ONE, 2013
Nonhomologous end-joining (NHEJ) and homologous recombination (HR) are two major pathways for repairing DNA double-strand breaks (DSBs); however, their respective roles in human somatic cells remain to be elucidated.
Aya Kurosawa, Shinta Saito, Sairei So, Mitsumasa Hashimoto, Kuniyoshi Iwabuchi, Haruka Watabe, Noritaka Adachi   +6 more
doaj   +2 more sources

BRCA1 Is a Histone-H2A-Specific Ubiquitin Ligase [PDF]

Cell Reports, 2014
The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and for silencing at DNA satellite repeat regions. Despite its links to chromatin,
Reinhard Kalb, Donna L. Mallery, Conor Larkin, Jeffrey T.J. Huang, Kevin Hiom   +4 more
doaj   +9 more sources

DNA Ligase I Is Not Essential for Mammalian Cell Viability [PDF]

Cell Reports, 2014
Summary: Of the three DNA ligases present in all vertebrates, DNA ligase I (Lig1) has been considered essential for ligating Okazaki fragments during DNA replication and thereby essential for cell viability.
Li Han, Shahnaz Masani, Chih-lin Hsieh, Kefei Yu   +3 more
doaj   +3 more sources

ATP-dependent DNA ligases [PDF]

Genome biology, 2002
By catalyzing the joining of breaks in the phosphodiester backbone of duplex DNA, DNA ligases play a vital role in the diverse processes of DNA replication, recombination and repair.
MacNeill, Stuart A, Martin, Ina V
core   +5 more sources

Structural and mechanistic conservation in DNA ligases [PDF]

Nucleic Acids Research, 2000
DNA ligases are enzymes required for the repair, replication and recombination of DNA. DNA ligases catalyse the formation of phosphodiester bonds at single-strand breaks in double-stranded DNA. Despite their occurrence in all organisms, DNA ligases show a wide diversity of amino acid sequences, molecular sizes and properties.
Aidan J. Doherty
openalex   +4 more sources