Results 201 to 210 of about 182,062 (331)

Rapid discovery of functional RNA domains. [PDF]

Nucleic Acids Res
Latifi B, Cole KH, Vu MMK, Lupták A.
europepmc   +1 more source

Inhibiting NHEJ in HNSCC cell lines by the ligase IV inhibitor SCR130 has limited radiosensitizing effects. [PDF]

Sci Rep
Hildebrand LS, Jost T, Schindler M, Derer A, Fuhrmann G, Fietkau R, Distel LV.   +6 more
europepmc   +1 more source

Protonated Glutamate and Aspartate Side Chains Can Recognize Phosphodiester Groups via Strong and Short Hydrogen Bonds in Biomacromolecular Complexes

Angewandte Chemie International Edition, EarlyView.
The highly negatively charged phosphodiester groups of nucleic acids and cyclic (di‐)nucleotides often interact with amino acids containing polar or positively charged sidechains. Due to charge repulsion with their negatively charged carboxylate groups in their side chains, glutamate and aspartate are considered to be detrimental to such interactions ...
Konstantin Neißner, Elke Duchardt‐Ferner, Christoph Wiedemann, Julian Kraus, Ute A. Hellmich, Jens Wöhnert   +5 more
wiley   +1 more source

ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213. [PDF]

Nat Commun
Ahel J, Balci A, Faas V, Grabarczyk DB, Harmo R, Squair DR, Zhang J, Roitinger E, Lamoliatte F, Mathur S, Deszcz L, Bell LE, Lehner A, Williams TL, Sowar H, Meinhart A, Wood NT, Clausen T, Virdee S, Fletcher AJ.   +19 more
europepmc   +1 more source

Mixing and Matching of Hybrid Megasynthases is a Hub for the Evolution of Metabolic Diversity in Cyanobacteria

Angewandte Chemie International Edition, EarlyView.
Natural combinatorics: Evolutionary mixing and matching of three cyanobacterial biosynthetic gene clusters resulted in the emergence of minutumamides, a novel family of peptide‐polyketide hybrids. Retro‐evolutionary analysis led to the discovery of nostopeptolide KVJ3, an evolutionary ancestor that links nostopeptolide and minutumamide biosynthesis and
Keishi Ishida, Qi Sun, Jonna Teikari, Christian Hertweck, Elke Dittmann, Masahiro Murakami, Martin Baunach   +6 more
wiley   +1 more source

Identification of an enzyme with strong single-stranded DNA ligation activity and its application for sequencing. [PDF]

Nucleic Acids Res
Miura F, Shibata Y, Miura M, Inatomi K, Suzuki Y, Ito T.   +5 more
europepmc   +1 more source

Biochemical characterization of a thermostable DNA ligase from the hyperthermophilic euryarchaeon Thermococcus barophilus Ch5

Applied Microbiology and Biotechnology, 2019
Haoqiang Shi, Yanchao Huang, Qi Gan, Mianwen Rui, Hongxun Chen, Chuandeng Tu, Zhihui Yang, P. Oger, Likui Zhang   +8 more
semanticscholar   +2 more sources

Role of Human DNA Ligases in Mediating Pharmacological Activities of Flavonoids. [PDF]

Int J Mol Sci
Sun D, Gokhale V.
europepmc   +1 more source

An Update: Enzymatic Synthesis for Industrial Applications

Angewandte Chemie International Edition, EarlyView.
Biocatalysis has become a sustainable and cost‐competitive alternative to established chemical synthesis, enabling the enzyme‐based production of not only commodity chemicals but (non‐natural) amino acids, (rare) sugars, as well as synthetic nucleotides.
Thomas Bayer, Shuke Wu, Radka Snajdrova, Kai Baldenius, Uwe T. Bornscheuer   +4 more
wiley   +1 more source

Large scale identification of pellicle and cell-free liquid phase associated proteins in <i>Bacillus amyloliquefaciens</i> L-17. [PDF]

Curr Res Microb Sci
Ouidir T, Hardouin J, Marcato-Romain CE, Girbal-Neuhauser E, Nait Chabane Y.   +4 more
europepmc   +1 more source