Results 241 to 250 of about 145,020 (273)

Nick sealing of polβ mismatch insertion products by LIG1 and LIG3α during 8-oxoG bypass leads to mutagenic or error-free base excision repair. [PDF]

J Biol Chem
Lee KM, Castro E, Ratcliffe J, Lerner C, Çağlayan M.   +4 more
europepmc   +1 more source

Identification of a Proteolysis‐Targeting‐Chimera that Addresses Activated Checkpoint Kinase‐1 Reveals its Non‐Catalytic Functions in Tumor Cells

Angewandte Chemie International Edition, EarlyView.
In cancer cells, the induction of DNA replication stress by HU activates CHK1 by autophosphorylation. This leads to cell cycle arrest and recruits the DNA repair protein WRN to promote DNA repair and cell survival. In such cells, addition of the CHK1 inhibitor 9a propels DNA damage and apoptosis.
Ramy Ashry, Mohamed Abdelsalam, Julia Hausen, Christoph Hieber, Yanira Zeyn, Anne‐Christin Sarnow, Matthias Schmidt, Sara Najafi, Ina Oehme, Matthias Bros, Jia‐Xuan Chen, Mario Dejung, Wolfgang Sippl, Oliver H. Krämer   +13 more
wiley   +1 more source

Mitochondrial proteins as biomarkers of cellular senescence and age-associated diseases. [PDF]

Aging (Albany NY)
Panfilova A, Zubareva T, Mironova E, Mazzoccoli G, Marasco MGP, Balazovskaia S, Yablonsky P, Kvetnoy I.   +7 more
europepmc   +1 more source

Overexpression, Purification, and Biochemical Characterization of the vanC2 d-Ala-d-Ser Ligase from <i>Enterococcus casseliflavus</i> SSK and Its Inhibition by an Oxadiazole Derivative. [PDF]

ACS Omega
Paymal SB, Barale SS, Supanekar SV, Sonawane KD, Pawar KD.   +4 more
europepmc   +1 more source

Targeting mitochondrial structure and dynamics for therapeutic intervention in cancer. [PDF]

PLoS Biol
Iwata W, Haggerty N, Sesaki H, Iijima M.
europepmc   +1 more source

Inflammatory mitochondrial signalling and viral mimicry in cancer. [PDF]

J Transl Med
Nesci S, Marchi S, Hu J, Marincola FM, Algieri C.   +4 more
europepmc   +1 more source

Cold stress enhances cryotolerance in <i>Lacticaseibacillus rhamnosus</i> B6 via membrane lipid remodeling and differential protein expression. [PDF]

Curr Res Microb Sci
Yang T, Zhang J, Zhang R, Zhang J, Liu Z, Wu Z.   +5 more
europepmc   +1 more source

Revitalizing equine metabolism: how SHBG improves mitochondrial function and reduces inflammation. [PDF]

BMC Vet Res
Bourebaba N, Domagała J, Bourebaba L.
europepmc   +1 more source

Involvement of <i>ACSM</i> family genes in the reprogramming of lipid metabolism within tumors and their investigation as promising therapeutic targets. [PDF]

Front Cell Dev Biol
Fang KX, Li ZQ, Dong JL, Yu Z.
europepmc   +1 more source