Results 301 to 310 of about 182,062 (331)

The closed conformation of ATP-dependent DNA ligase from Archaeoglobus fulgidus

, 2009
D. J. Kim, H.-W. Kim, O. Kim, H.S. Kim, S.J. Lee, Se-Won Suh   +5 more
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Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.

Organic and biomolecular chemistry, 2015
DNA ligases are critical components for DNA metabolism in all organisms. NAD(+)-dependent DNA ligases (LigA) found exclusively in bacteria and certain entomopoxviruses are drawing increasing attention as therapeutic targets as they differ in their ...
N. Yadav, Taran Khanam, A. Shukla, N. Rai, K. Hajela, R. Ramachandran   +5 more
semanticscholar   +1 more source

mycobacterial DNA ligase D complexed with ATP and MES

, 2019
S. Shuman, M. Unciuleac, Y. Goldgur
semanticscholar   +1 more source

E3 ligase ligand chemistries: from building blocks to protein degraders

Chemical Society Reviews, 2022
Izidor Sosi, Aleša Bricelj, Christian Steinebach   +2 more
exaly  

mycobacterial DNA ligase D complexed with ATP and Mg

, 2019
S. Shuman, M. Unciuleac, Y. Goldgur
semanticscholar   +1 more source

E3 Ligase Ligands in Successful PROTACs: An Overview of Syntheses and Linker Attachment Points

Frontiers in Chemistry, 2021
Aleša Bricelj, Christian Steinebach, Michael Gütschow   +2 more
exaly  

Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders

Chemical Society Reviews, 2022
Claudia J Diehl, Alessio Ciulli
exaly  

Interaction of beta-L-adenosine-5 '-triphosphate (L-ATP) with human deoxycytidine kinase, human DNA primase and T4 DNA ligase: Does the chance direct enzymatic enantioselectivity?

1999
We demonstrate that L-ATP: 1) as well as its natural D-enantiomer, acts as a phosphate donor in the reaction catalysed by human deoxycytidine kinase; 2) inhibits human DNA-primase and the ATP-dependent T4 DNA ligase. Thus, the lack of enantioselectivity of the enzymes is more frequent than it was believed a few years ago and we suggest that it would ...
Verri A, Montecucco A, Gosselin G, Boudou V, Spadari S, Focher F   +5 more
openaire   +1 more source

SCF ubiquitin ligase-targeted therapies

Nature Reviews Drug Discovery, 2014
Julia K Pagan, Michele Pagano
exaly  

Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide

Nature, 2014
Eric S Fischer, Michael B Stadler, Simone Cavadini   +2 more
exaly