Results 41 to 50 of about 113,019 (248)

The eukaryotic Pso2/Snm1/Artemis proteins and their function as genomic and cellular caretakers

Brazilian Journal of Medical and Biological Research, 2005
DNA double-strand breaks (DSBs) represent a major threat to the genomic stability of eukaryotic cells. DNA repair mechanisms such as non-homologous end joining (NHEJ) are responsible for the maintenance of eukaryotic genomes.
D. Bonatto, L.F. Revers, M. Brendel, J.A.P. Henriques   +3 more
doaj   +1 more source

Mutation-Driven Divergence and Convergence Indicate Adaptive Evolution of the Intracellular Human-Restricted Pathogen, Bartonella bacilliformis. [PDF]

PLoS Neglected Tropical Diseases, 2016
Among all species of Bartonella, human-restricted Bartonella bacilliformis is the most virulent but harbors one of the most reduced genomes. Carrión's disease, the infection caused by B.
Sandip Paul, Michael F Minnick, Sujay Chattopadhyay   +2 more
doaj   +1 more source

A functional and structural study of three bacterial nucleic acid-interacting proteins. The story of a Ferric Uptake Regulator, an Oligoribonuclease and an ATP-dependent DNA ligase

, 2020
Nucleic acid-interacting proteins are essential players in cellular processes of all living organisms. In the present study, we explore three psychrophilic-derived proteins involved in gene regulation, RNA degradation and DNA ligation in bacterial cells, with one common feature; they perform their activity by interacting with nucleic acids.
Kristel Berg
openalex   +2 more sources

Transcriptome-wide analysis reveals core transcriptional regulators associated with culm development and variation in Dendrocalamus sinicus, the strongest woody bamboo in the world

Heliyon, 2022
Transcription factors (TFs) play indispensable roles in plant development and stress responses. As the largest woody bamboo species in the world, Dendrocalamus sinicus is endemic to Yunnan Province, China, and possesses two natural variants characterized
Lingna Chen, Peitong Dou, Lushuang Li, Yongkun Chen, Hanqi Yang   +4 more
doaj   +1 more source

The chromatin remodeler CHD6 promotes colorectal cancer development by regulating TMEM65-mediated mitochondrial dynamics via EGF and Wnt signaling

Cell Discovery, 2022
Chromodomain helicase DNA binding protein (CHD) family plays critical roles in regulating gene transcription. The family is linked to cancer disease, but the family member’s role in tumorigenesis remains largely unknown.
Boyu Zhang, Qingxin Liu, Weijie Wen, Han Gao, Wenxia Wei, Aiwen Tang, Baifu Qin, Haiwen Lyu, Xiangqi Meng, Kai Li, Huilin Jin, Fenghai Yu, Qihao Pan, Junzhong Lin, Mong-Hong Lee   +14 more
doaj   +1 more source

Bioinformatics analysis of genes of Streptomyces xinghaiensis (fradiae) ATCC 19609 with a focus on mutations conferring resistance to oligomycin A and its derivatives

Journal of Global Antimicrobial Resistance, 2020
Objectives: The aim of this study was to obtain Streptomyces xinghaiensis (fradiae) ATCC 19609 mutants resistant to oligomycin A and its derivatives and to identify the underlying mechanism of resistance.
Aleksey A. Vatlin, Olga B. Bekker, Ludmila N. Lysenkova, Andrey E. Shchekotikhin, Valery N. Danilenko   +4 more
doaj   +1 more source

Growth arrest and DNA damage‐inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Skeletal muscle fat infiltration is a common feature during ageing, obesity and several myopathies associated with muscular dysfunction and sarcopenia.
Wenjing You, Shiqi Liu, Jianfei Ji, Defeng Ling, Yuang Tu, Yanbing Zhou, Wentao Chen, Teresa G. Valencak, Yizhen Wang, Tizhong Shan   +9 more
doaj   +1 more source

In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast

Cell Reports, 2019
Summary: Disassembly of the replisome is the final step of chromosome duplication in eukaryotes. In budding yeast and metazoa, cullin ubiquitin ligases are required to ubiquitylate the Cdc45-MCM-GINS (CMG) helicase that lies at the heart of the replisome,
Progya P. Mukherjee, Karim P.M. Labib
doaj   +1 more source

Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.

PLoS Genetics, 2014
Fbh1, an F-box helicase related to bacterial UvrD, has been proposed to modulate homologous recombination in fission yeast. We provide several lines of evidence for such modulation.
Yasuhiro Tsutsui, Yumiko Kurokawa, Kentaro Ito, Md Shahjahan P Siddique, Yumiko Kawano, Fumiaki Yamao, Hiroshi Iwasaki   +6 more
doaj   +1 more source

Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway

Journal of Translational Medicine, 2023
Background Denervation-induced muscle atrophy is complex disease involving multiple biological processes with unknown mechanisms. N6-methyladenosine (m6A) participates in skeletal muscle physiology by regulating multiple levels of RNA metabolism, but its
Junjie Sun, Hai Zhou, Zehao Chen, Han Zhang, Yanzhe Cao, Xinlei Yao, Xin Chen, Boya Liu, Zihui Gao, Yuntian Shen, Lei Qi, Hualin Sun   +11 more
doaj   +1 more source