Results 21 to 30 of about 1,734,103 (274)

Characterization of an ATP-dependent DNA ligase encoded by Chlorella virus PBCV-1 [PDF]

Journal of Virology, 1997
We report that Chlorella virus PBCV-1 encodes a 298-amino-acid ATP-dependent DNA ligase. The PBCV-1 enzyme is the smallest member of the covalent nucleotidyl transferase superfamily, which includes the ATP-dependent polynucleotide ligases and the GTP-dependent RNA capping enzymes.
Ho, C. Kiong, Van Etten, James L., Shuman, Stewart   +2 more
openaire   +2 more sources

The molecular basis of CRL4 ubiquitin ligase architecture, targeting and regulation [PDF]

, 2013
Members of the CUL4-RBX1-DDB1 (CRL4) E3 ubiquitin ligase family regulate multiple cellular processes including development, transcription, and DNA repair.
Fischer, Eric Sebastian
core   +1 more source

Evolution of DNA ligases of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes: a case of hidden complexity

Biology Direct, 2009
Background Eukaryotic Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) encode most if not all of the enzymes involved in their DNA replication. It has been inferred that genes for these enzymes were already present in the last common ancestor of the NCLDV ...
Koonin Eugene V, Yutin Natalya
doaj   +1 more source

BRCA1 is a histone-H2A-specific ubiquitin ligase [PDF]

, 2014
The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and for silencing at DNA satellite repeat regions. Despite its links to chromatin,
Donna L. Mallery, Mallery, D., Conor Larkin, Huang, Jeffrey T.J., Kalb, R., Kevin Hiom, Kalb, Reinhard, Reinhard Kalb, Huang, Jeffrey T. J.; id_orcid, Hiom, Kevin, Hiom, K., Jeffrey T.J. Huang, Larkin, C., Mallery, Donna L., Larkin, Conor, Huang, J.   +15 more
core   +1 more source

Cloning, expression, and chromosomal localization of the 140-kilodalton subunit of replication factor C from mice and humans [PDF]

, 1994
We have isolated a full-length mouse cDNA encoding a lysine-rich protein of 1,131 amino acids with a calculated molecular mass of 126 kDa. The protein binds in a sequence-unspecific manner to DNA, is localized exclusively in the nucleus, and contains a ...
Schütz, Günther, Stillman, B., Bunz, F., Lichter, P., Luckow, Bruno   +4 more
core   +2 more sources

Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA [PDF]

, 2011
How tightly packed chromatin is thoroughly inspected for DNA damage is one of the fundamental unanswered questions in biology. In particular, the effective excision of carcinogenic lesions caused by the ultraviolet (UV) radiation of sunlight depends on ...
Naegeli, H, Nina Kaczmarek, Andreas Glas, Glas, Andreas, Carell Thomas, Glas, A, Carell, Thomas, Fei Jia, Kaczmarek Nina, Glas Andreas, Jia Fei, Carell, T, Andreas Luch, Naegeli Hanspeter, Fei, Jia, Naegeli, Hanspeter, Luch Andreas, Kaczmarek, Nina, Thomas Carell, Hanspeter Naegeli, Luch, A, Luch, Andreas, Fei, J, Kaczmarek, N, Luch, A., Fei, J., Carell, T., Kaczmarek, N., Glas, A., Naegeli, H.   +29 more
core   +2 more sources

Impact of DNA ligase IV on nonhomologous end joining pathways during class switch recombination in human cells [PDF]

, 2005
Class switch recombination (CSR) is a region-specific, transcriptionally regulated, nonhomologous recombinational process that is initiated by activation-induced cytidine deaminase (AID).
Lennart Hammarström, Hammarström, L,, Lahdesmaki, A, Aleksi Lähdesmäki, Wei Zhou, Andrew R. Gennery, Jones, AM, Michael R. Ehrenstein, Pan-Hammarstrom, Q, Hammarstrom, L, Zhou, W, Gennery, AR, Ehrenstein, MR, Anne-Marie Jones, Richard A. Gatti, Gatti, RA, Qiang Pan-Hammarström   +16 more
core   +1 more source

Characterization of a Thermophilic ATP-Dependent DNA Ligase from the Euryarchaeon Pyrococcus horikoshii [PDF]

Journal of Bacteriology, 2005
ABSTRACT Archaea encode a DNA ligase composed of a C-terminal catalytic domain typical of ATP-dependent ligases plus an N-terminal domain similar to that found in eukaryotic cellular and poxvirus DNA ligases. All archaeal DNA ligases characterized to date have ATP-dependent adenylyltransferase and nick-joining activities. However,
Niroshika, Keppetipola, Stewart, Shuman
openaire   +2 more sources

Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis [PDF]

, 2013
ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis, thus representing ...
Nicholas H Keep, Munshi, T, Sanjib Bhakta (106475), Bhakta, S, Gupta, A, Gibbons, S., Simon Gibbons (391868), Nicholas H. Keep (392673), Antima Gupta, Keep, Nicholas H., Gibbons, Simon, Bhakta, Sanjib, Evangelopoulos, Dimitrios, Juan David Guzman (392672), Gibbons, S, Simon Gibbons, Dimitrios Evangelopoulos (392671), Tulika Munshi (392669), Antima Gupta (392670), Juan David Guzman, Evangelopoulos, D, Guzman, Juan David, Gupta, Antima, Dimitrios Evangelopoulos, Munshi, Tulika, Sanjib Bhakta, Keep, NH, Guzman, Juan D., Guzman, JD, Tulika Munshi   +29 more
core   +1 more source

ATPase-dependent control of the Mms21 SUMO ligase during DNA repair.

PLoS Biology, 2015
Modification of proteins by SUMO is essential for the maintenance of genome integrity. During DNA replication, the Mms21-branch of the SUMO pathway counteracts recombination intermediates at damaged replication forks, thus facilitating sister chromatid ...
Marcelino Bermúdez-López, Irene Pociño-Merino, Humberto Sánchez, Andrés Bueno, Clàudia Guasch, Seba Almedawar, Sergi Bru-Virgili, Eloi Garí, Claire Wyman, David Reverter, Neus Colomina, Jordi Torres-Rosell   +11 more
doaj   +1 more source