Results 31 to 40 of about 78,437 (236)

Bleomycin-induced DNA repair by Saccharomyces cerevisiae ATP-dependent polydeoxyribonucleotide ligase [PDF]

Journal of Bacteriology, 1988
In contrast to ligase-deficient (cdc9) Saccharomyces cerevisiae, which did not rejoin bleomycin-induced DNA breaks, ligase-proficient (CDC9) yeast cells eliminated approximately 90% of DNA breaks within 90 to 120 min after treatment. Experimental conditions restricted enzymatic removal of the unusual 3'-phosphoglycolate termini in DNA cleaved by ...
openaire   +2 more sources

Bioinformatics analysis of genes of Streptomyces xinghaiensis (fradiae) ATCC 19609 with a focus on mutations conferring resistance to oligomycin A and its derivatives

Journal of Global Antimicrobial Resistance, 2020
Objectives: The aim of this study was to obtain Streptomyces xinghaiensis (fradiae) ATCC 19609 mutants resistant to oligomycin A and its derivatives and to identify the underlying mechanism of resistance.
Aleksey A. Vatlin, Olga B. Bekker, Ludmila N. Lysenkova, Andrey E. Shchekotikhin, Valery N. Danilenko   +4 more
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Growth arrest and DNA damage‐inducible alpha regulates muscle repair and fat infiltration through ATP synthase F1 subunit alpha

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Skeletal muscle fat infiltration is a common feature during ageing, obesity and several myopathies associated with muscular dysfunction and sarcopenia.
Wenjing You, Shiqi Liu, Jianfei Ji, Defeng Ling, Yuang Tu, Yanbing Zhou, Wentao Chen, Teresa G. Valencak, Yizhen Wang, Tizhong Shan   +9 more
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In Vitro Reconstitution Defines the Minimal Requirements for Cdc48-Dependent Disassembly of the CMG Helicase in Budding Yeast

Cell Reports, 2019
Summary: Disassembly of the replisome is the final step of chromosome duplication in eukaryotes. In budding yeast and metazoa, cullin ubiquitin ligases are required to ubiquitylate the Cdc45-MCM-GINS (CMG) helicase that lies at the heart of the replisome,
Progya P. Mukherjee, Karim P.M. Labib
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ATP-dependent DNA ligase fromArchaeoglobus fulgidusdisplays a tightly closed conformation [PDF]

Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2009
DNA ligases join the breaks in double-stranded DNA by catalyzing the formation of a phosphodiester bond between adjacent 3'-hydroxyl and 5'-phosphate termini. They fall into two classes that require either ATP or NAD(+) as the source of an AMP group that is covalently attached to a strictly conserved lysine.
Do Jin, Kim, Olesya, Kim, Hyeon Woo, Kim, Hyoun Sook, Kim, Sang Jae, Lee, Se Won, Suh   +5 more
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Multiple regulation of Rad51-mediated homologous recombination by fission yeast Fbh1.

PLoS Genetics, 2014
Fbh1, an F-box helicase related to bacterial UvrD, has been proposed to modulate homologous recombination in fission yeast. We provide several lines of evidence for such modulation.
Yasuhiro Tsutsui, Yumiko Kurokawa, Kentaro Ito, Md Shahjahan P Siddique, Yumiko Kawano, Fumiaki Yamao, Hiroshi Iwasaki   +6 more
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Altered m6A RNA methylation governs denervation-induced muscle atrophy by regulating ubiquitin proteasome pathway

Journal of Translational Medicine, 2023
Background Denervation-induced muscle atrophy is complex disease involving multiple biological processes with unknown mechanisms. N6-methyladenosine (m6A) participates in skeletal muscle physiology by regulating multiple levels of RNA metabolism, but its
Junjie Sun, Hai Zhou, Zehao Chen, Han Zhang, Yanzhe Cao, Xinlei Yao, Xin Chen, Boya Liu, Zihui Gao, Yuntian Shen, Lei Qi, Hualin Sun   +11 more
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A cost-effective method for Illumina small RNA-Seq library preparation using T4 RNA ligase 1 adenylated adapters

Plant Methods, 2012
Background Deep sequencing is a powerful tool for novel small RNA discovery. Illumina small RNA sequencing library preparation requires a pre-adenylated 3’ end adapter containing a 5’,5’-adenyl pyrophosphoryl moiety.
Chen Yun-Ru, Zheng Yi, Liu Bao, Zhong Silin, Giovannoni Jim, Fei Zhangjun   +5 more
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Ataxia-telangiectasia mutated interacts with Parkin and induces mitophagy independent of kinase activity. Evidence from mantle cell lymphoma

Haematologica, 2020
Ataxia telangiectasia mutated (ATM), a critical DNA damage sensor with protein kinase activity,is frequently altered in human cancers including mantle cell lymphoma (MCL).
Aloke Sarkar, Christine M. Stellrecht, Hima V. Vangapandu, Mary Ayres, Benny A. Kaipparettu, Jun Hyoung Park, Kumudha Balakrishnan, Jared K. Burks, Tej K. Pandita, Walter N. Hittelman, Sattva S. Neelapu, Varsha Gandhi   +11 more
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Baicalein resensitizes tamoxifen‐resistant breast cancer cells by reducing aerobic glycolysis and reversing mitochondrial dysfunction via inhibition of hypoxia‐inducible factor‐1α

Clinical and Translational Medicine, 2021
Drug resistance is a major hurdle for the effectiveness of tamoxifen (TAM) to provide clinical benefit. Therefore, it is essential to identify a sensitizer that could be used to improve TAM efficacy in treating TAM‐resistant breast cancer.
Yan Chen, Jingyu Zhang, Minqin Zhang, Yuxuan Song, Yue Zhang, Shuangqin Fan, Shuang Ren, Lingyun Fu, Nenling Zhang, Hui Hui, Xiangchun Shen   +10 more
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