Results 231 to 240 of about 77,898 (323)

Crystal structure of ATP-dependent DNA ligase from Rhizobium phage vB_RleM_P10VF. [PDF]

Acta Crystallogr F Struct Biol Commun
Rothweiler U, Leiros HKS, Williamson A.
europepmc   +1 more source

Identification of a Mutated DNA Ligase IV Gene in the X-ray-hypersensitive Mutant SX10 of Mouse FM3A Cells [PDF]

, 2001
Katsuyuki Sado, Dai Ayusawa, Atsusi Enomoto, Tsutomu Suganuma, Mitsuo Oshimura, Koki Sato, Hidenori Koyama   +6 more
openalex   +1 more source

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway

Advanced Science, EarlyView.
Relapsed and refractory multiple myeloma remains a major clinical challenge. This study shows that FOXM1 contributes to resistance against BH3 mimetics in multiple myeloma cells. The FOXM1 inhibitor NB73 enhances the effectiveness of BH3 mimetics by reducing FOXM1 expression and suppressing the MYC pathway.
Zhi Wen, Yidan Wang, Kathryn C. Fox, Adam M. Bissonnette, Luke F. Moat, Terrie E. Kitchner, Kelsey Springstroh, Sung Hoon Kim, Dagna S. Sheerar, Patcharon Tanawattanacharoen, Chady A. Leon, Seth O. Fagbemi, John A. Katzenellenbogen, Scott J. Hebbring, Benita S. Katzenellenbogen, Siegfried Janz, Adedayo A. Onitilo   +16 more
wiley   +1 more source

Berberine Sensitises Breast Cancer Cells to Radiation via the Attenuation of DNA Ligase III. [PDF]

J Cell Mol Med
Sun Y, Li C, Yin H, Li K, Wang Y, Zhang S, Zhao Y, Wang J, Mao W.   +8 more
europepmc   +1 more source

Structure and function of the DNA ligases encoded by the mammalian LIG3 gene. [PDF]

Gene, 2013
Tomkinson AE, Sallmyr A.
europepmc   +1 more source

Role of DNA Ligase in the Illegitimate Recombination That Generates λbio-Transducing Phages in Escherichia coli [PDF]

, 2001
Masaaki Onda, Junko Yamaguchi, Katsuhiro Hanada, Yasuo Asami, Hideo Ikeda   +4 more
openalex   +1 more source

Mixed Lineage Kinase Domain‐Like Protein (MLKL): From Mechanisms to Therapeutic Opportunities

Advanced Science, EarlyView.
The mixed lineage kinase domain‐like protein (MLKL) acts as the executioner in the necroptosis pathway, transitioning from an inactive to active state through phosphorylation, oligomerization, membrane recruitment, and membrane insertion, ultimately forming membrane hotpots.
Lijuan Xu, Chunlin Zhuang
wiley   +1 more source

Antisense-mediated decrease in DNA ligase III expression results in reduced mitochondrial DNA integrity [PDF]

, 2001
Uma Lakshmipathy
openalex   +1 more source

Enhancer Reprogramming Reveals the Tumorigenic Role of PTPRZ1 in Lung Squamous Cell Carcinoma

Advanced Science, EarlyView.
Lung squamous cell cancer (LUSC) is deadly due to lack of good treatments. Here, multiomics techniques are applied to LUSC tumors and find thousands of cancer‐specific enhancers controlling key genes. Interestingly, the gene PTPRZ1 is identified as a critical oncogene driven by the LUSC‐acquired enhancers. PTPRZ1 is activated by MDK, fueling cancer via
Yong‐Qiang Ning, Jie Wang, Yihui Zhang, Hongrui Li, Zenan Jiang, Xinyu Su, Xiao Yang, Xiaoxuan Wu, Bing Wei, Jianmin Ying, Jian Yan, Wenbin Li   +11 more
wiley   +1 more source

Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment. [PDF]

Front Immunol
Zhang K, Yuan H, Shi L.
europepmc   +1 more source