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Eukaryotic DNA Ligases and DNA Repair
1998The correct joining of appropriate DNA ends is a fundamental step in many important reactions within the cell and a number of enzymes have been identified which perform these end-joining reactions. Some enzymes execute a ligation step as an intermediate of their overall reaction mechanism; DNA topoisomerases are a prime example of this type of activity
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1982
Publisher Summary DNA ligases refer to enzymes that catalyze the formation of a phosphodiester linkage between DNA chains. DNA ligases are essential reagents in studies on nucleic acid structure and metabolism. Their value derives from the specificity of the reaction and their ability to join polynucleotide chains covalently.
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Publisher Summary DNA ligases refer to enzymes that catalyze the formation of a phosphodiester linkage between DNA chains. DNA ligases are essential reagents in studies on nucleic acid structure and metabolism. Their value derives from the specificity of the reaction and their ability to join polynucleotide chains covalently.
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DNA Ligases: Structure, Reaction Mechanism, and Function
Chemical Reviews, 2006Alan Tomkinson +2 more
exaly
Structural and mechanistic conservation in DNA ligases
Nucleic Acids Research, 2000Se Won Suh, Aidan Doherty, Suh Se Won
exaly
Eukaryotic DNA Ligases: Structural and Functional Insights
Annual Review of Biochemistry, 2008Alan Tomkinson, Tom Ellenberger
exaly