Results 201 to 210 of about 54,630 (258)
Ubiquitination mediated by RING-type E3 ligases in the progression of digestive system tumors: mechanistic insights and potential therapeutic strategies. [PDF]
Wu Y, Yu X, Guan C, Zhao M.
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Reprogramming of the hepatic ubiquitin‑immune axis: A unifying mechanism in liver disease progression (Review). [PDF]
Ju Y +5 more
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Holding the PP2A and PP4 protein phosphatases at bay: emerging roles of FBXO42 and CCDC6. [PDF]
Nilsson J.
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Mutation Research DNA Repair, 1990
Recent studies on eukaryotic DNA ligases are briefly reviewed. The two distinguishable enzymes from mammalian cells, DNA ligase I and DNA ligase II, have been purified to homogeneity and characterized biochemically. Two distinct DNA ligases have also been identified in Drosophila melanogaster embryos.
Alan E Tomkinson +2 more
exaly +3 more sources
Recent studies on eukaryotic DNA ligases are briefly reviewed. The two distinguishable enzymes from mammalian cells, DNA ligase I and DNA ligase II, have been purified to homogeneity and characterized biochemically. Two distinct DNA ligases have also been identified in Drosophila melanogaster embryos.
Alan E Tomkinson +2 more
exaly +3 more sources
Current Protocols in Molecular Biology, 2011
AbstractThe DNA ligase enzyme family catalyzes the formation of a phosphodiester bond between juxtaposed 5′‐phosphate and 3′‐hydroxyl termini in duplex DNA. This activity can seal nicks in duplex DNA or join double‐stranded DNA fragments having either blunt or cohesive ends.
Gregory J S, Lohman +2 more
openaire +2 more sources
AbstractThe DNA ligase enzyme family catalyzes the formation of a phosphodiester bond between juxtaposed 5′‐phosphate and 3′‐hydroxyl termini in duplex DNA. This activity can seal nicks in duplex DNA or join double‐stranded DNA fragments having either blunt or cohesive ends.
Gregory J S, Lohman +2 more
openaire +2 more sources
BioEssays, 1997
AbstractDNA joining enzymes play an essential role in the maintenance of genomic integrity and stability. Three mammalian genes encoding DNA ligases, LIG1, LIG3 and LIG4, have been identified. Since DNA ligase II appears to be derived from DNA ligase III by a proteolytic mechanism, the three LIG genes can account for the four biochemically distinct DNA
A E, Tomkinson, D S, Levin
openaire +2 more sources
AbstractDNA joining enzymes play an essential role in the maintenance of genomic integrity and stability. Three mammalian genes encoding DNA ligases, LIG1, LIG3 and LIG4, have been identified. Since DNA ligase II appears to be derived from DNA ligase III by a proteolytic mechanism, the three LIG genes can account for the four biochemically distinct DNA
A E, Tomkinson, D S, Levin
openaire +2 more sources

