Results 181 to 190 of about 81,432 (342)
DNA Ligase III Is Degraded by Calpain during Cell Death Induced by DNA-damaging Agents
, 2002 Laura Bordone, Colin Campbell
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Genome biology, 2002 By catalyzing the joining of breaks in the phosphodiester backbone of duplex DNA, DNA ligases play a vital role in the diverse processes of DNA replication, recombination and repair. Three related classes of ATP-dependent DNA ligase are readily apparent in eukaryotic cells.
Ina V, Martin, Stuart A, MacNeill
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Advanced Science, EarlyView.Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo +7 more
wiley +1 more source
Role of Human DNA Ligases in Mediating Pharmacological Activities of Flavonoids. [PDF]
Int J Mol SciSun D, Gokhale V.
europepmc +1 more source
Polynucleotide 3'-terminal phosphate modifications by RNA and DNA ligases. [PDF]
J Biol Chem, 2014 Zhelkovsky AM, McReynolds LA.
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Substrate Targeting and Control of DNA Replication by the CUL4/DDB1 Ubiquitin Ligase
, 2019 Chad M. McCall
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Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, EarlyView.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
The yeast CDC9 gene encodes both a nuclear and a mitochondrial form of DNA ligase I [PDF]
, 1999 Martin Willer +3 more
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