Results 241 to 250 of about 2,144,804 (323)

WWP1 knockout in mice exacerbates obesity-related phenotypes in white adipose tissue but improves whole-body glucose metabolism [PDF]

, 2020
Abe, T., Furuya, K., Higami, Y., Hoshino, S., Kawabe, H., Kobayashi, M., Konno, R., Miura, K., Mizunoe, Y., Nakagawa, Y., Nakamura, T., Okita, N., Sudo, Y., Tagawa, R., Wakasawa, H.   +14 more
core   +1 more source

Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis

Advanced Science, EarlyView.
Aging involves physiological decline and heightened disease susceptibility, necessitating effective interventions. Redox‐responsive selenium‐loaded nanoparticles (SeMSNs) are developed, which delay cellular senescence by reducing oxidative stress and senescence markers (p16/p21). In aged mice, SeMSNs extend lifespan, improve organ function, and restore
Yang Yu, Jintao Song, Mengjiao Guo, RuZe Ma, Mingyang Du, Zhe Xun, Xu Liu, RongXia Xu, Xiaochun Xie, Peilin Qi, Yujie Chen, Dan Shao, Chao Yang, Liang Wang, Xiaoyu Song, Difei Wang   +15 more
wiley   +1 more source

A High Sensitivity Qcm Biosensor Based on Nanosilver Clusters and DNA Ligase for the Detection of the Braf-V600e Single Mutant Gene in Melanoma

Jia Guo, Ruming Liu, Yuan Ge, Rui-Qin Fang, Yixuan Wang, Yan Liu, Hanjia Jiang, Lixia Tang, Juan Feng, Fei Cao, Hongjuan Zeng   +10 more
openalex   +1 more source

Macromolecular crowding allows blunt-end ligation by DNA ligases from rat liver or Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America, 1983
S. Zimmerman, B. H. Pheiffer
semanticscholar   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

The enigma of the RING-UIM E3 ligases: its transformative impact on cancer research. [PDF]

J Transl Med
Wang Y, Zhao Y, Xin Q, Zhang J.
europepmc   +1 more source

Omenn syndrome is associated with mutations in DNA ligase IV [PDF]

, 2008
Eyal Grunebaum, Andrea Bates, Chaim M. Roifman   +2 more
openalex   +1 more source

The Crosstalk Between CRL5 and APC/C E3 Ligases Regulates Metastasis and Chemosensitivity of Cancer Cells

Advanced Science, EarlyView.
This study uncovers a previously unknown crosstalk between two major ubiquitin ligases, CRL5 and APC/C. The authors identify APC11 as a binding partner of CUL5, showing that their interaction regulates neddylation, substrate stability, and mitotic progression.
Danrui Cui, Ruirui Qu, Tianqi Li, Linchen Wang, Xiaoyu Chen, Shengpeng Shao, Xue Liang, Jun Xu, Yi Sun, Xiufang Xiong, Yongchao Zhao   +10 more
wiley   +1 more source

Functions and applications of enzymes in nucleic acid nanotechnology. [PDF]

J Nanobiotechnology
Rong Q, Chu Z, Xu Y, Ma L, Wang L, Wang S, Yin Z, Su X.   +7 more
europepmc   +1 more source

Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1–Dependent Apoptosis in Cancer Cells [PDF]

, 2016
Annahita Sallmyr, Yoshihiro Matsumoto, Vera Roginskaya, Bennett Van Houten, Alan E. Tomkinson   +4 more
openalex   +1 more source