Results 31 to 40 of about 2,144,804 (323)

DNA Ligase I Is Not Essential for Mammalian Cell Viability

Cell Reports, 2014
Summary: Of the three DNA ligases present in all vertebrates, DNA ligase I (Lig1) has been considered essential for ligating Okazaki fragments during DNA replication and thereby essential for cell viability.
Li Han, Shahnaz Masani, Chih-lin Hsieh, Kefei Yu   +3 more
doaj   +1 more source

Plant E3 Ligases and Their Role in Abiotic Stress Response

Cells, 2022
Plants, as sessile organisms, have limited means to cope with environmental changes. Consequently, they have developed complex regulatory systems to ameliorate abiotic stresses im-posed by environmental changes.
Raed Al-Saharin, Hanjo Hellmann, Sutton Mooney   +2 more
doaj   +1 more source

Sister chromatid telomere fusions, but not NHEJ-mediated inter-chromosomal telomere fusions, occur independently of DNA ligases 3 and 4

Genome Research, 2016
Telomeres shorten with each cell division and can ultimately become substrates for nonhomologous end-joining repair, leading to large-scale genomic rearrangements of the kind frequently observed in human cancers.
K. Liddiard, B. Ruis, Taylor Takasugi, Adam J. Harvey, K. Ashelford, E. Hendrickson, D. Baird   +6 more
semanticscholar   +1 more source

RBR E3 ubiquitin ligases: new structures, new insights, new questions [PDF]

, 2014
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex multidomain enzymes.
Shaw, Gary S., Spratt, Donald E., Walden, Helen   +2 more
core   +1 more source

SCF Ligases and Their Functions in Oogenesis and Embryogenesis—Summary of the Most Important Findings throughout the Animal Kingdom

Cells, 2022
SCF-dependent proteolysis was first discovered via genetic screening of budding yeast almost 25 years ago. In recent years, more and more functions of SCF (Skp1-Cullin 1-F-box) ligases have been described, and we can expect the number of studies on this ...
Veronika Kinterová, Jiří Kaňka, Alexandra Bartková, Tereza Toralová   +3 more
doaj   +1 more source

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining

Nucleic Acids Research, 2014
In mammalian cells, ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are repaired in all phases of the cell cycle predominantly by classical, DNA-PK-dependent nonhomologous end joining (D-NHEJ).
A. Soni, M. Siemann, Martha Grabos, T. Murmann, G. Pantelias, G. Iliakis   +5 more
semanticscholar   +1 more source

Identification of a novel motif in DNA ligases exemplified by DNA ligase IV [PDF]

, 2006
DNA ligase IV is an essential protein that functions in DNA non-homologous end-joining, the major mechanism that rejoins DNA double-strand breaks in mammalian cells. LIG4 syndrome represents a human disorder caused by mutations in DNA ligase IV that lead
Doherty, Aidan J, Jeggo, Penny, Marchetti, Caterina, Odreman, Federico, Vindigni, Alessandro, Walker, Sarah A   +5 more
core   +1 more source

The Inhibitory Effect of Non-Substrate and Substrate DNA on the Ligation and Self-Adenylylation Reactions Catalyzed by T4 DNA Ligase. [PDF]

PLoS ONE, 2016
DNA ligases are essential both to in vivo replication, repair and recombination processes, and in vitro molecular biology protocols. Prior characterization of DNA ligases through gel shift assays has shown the presence of a nick site to be essential for ...
Robert J Bauer, Thomas C Evans, Gregory J S Lohman   +2 more
doaj   +1 more source

Regulation of alphaherpesvirus infections by the ICP0 family of proteins [PDF]

, 2013
Immediate-early protein ICP0 of herpes simplex virus type 1 (HSV-1) is important for the regulation of lytic and latent viral infection. Like the related proteins expressed by other alphaherpesviruses, ICP0 has a zinc-stabilized RING finger domain that ...
Boutell, Chris, Everett, Roger
core   +1 more source

Label-free electrochemical monitoring of DNA ligase activity [PDF]

, 2008
This study presents a simple, label-free electrochemical technique for the monitoring of DNA ligase activity. DNA ligases are enzymes that catalyze joining of breaks in the backbone of DNA and are of significant scientific interest due to their essential
Ahel I., Bellamy S. R., Borodina T. A., Bullard D. R., Cahova-Kucharikova K., Cao W. G., Doherty A. J., Fadrna R., Fojta M., Fojta M., Fojta M., Fojta M., Fojta M., Fojta M., Friedberg E. C., Gowers D. M., Heiter D. F., Kucharikova K., Liu L. F., Palecek E., Pascal J. M., Rass U., Schrock R. D., Scott B. O. S., Shuman S., Tomkinson A. E., Vacek J., Wilkinson A., Wilkinson A., Zauner G.   +29 more
core   +1 more source