Results 121 to 130 of about 29,739 (230)
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
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Biomaterial Physical Cues as Gene Regulators for Cellular Agriculture
This review elucidates how biomaterial physical cues—ranging from matrix stiffness to remote electromagnetic fields—serve as extrinsic regulators of gene expression in cellular agriculture. By identifying central mechanotransduction pathways that bridge physical inputs to genetic remodeling, the authors propose the “Material Genome” concept: a ...
Jianuo Liu, Ye Liu
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Light‐Activated Nucleic Acid Amplification Systems Using Photo‐Caged DNA Polymerase or Primers
ABSTRACT Precise control over nucleic acid amplification is essential for achieving reliable, quantitative, high‐throughput, and multiplexed molecular diagnostics, particularly in point‐of‐care and field settings. However, conventional isothermal amplification methods, especially rapid assays at ambient temperature such as recombinase‐aided ...
Yang Wu +20 more
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ABSTRACT Primary refractory Diffuse Large B‐Cell Lymphoma is associated with poor outcomes and limited responsiveness to conventional salvage therapies. Although CAR T‐cell therapy represents the standard of care in this setting, a substantial proportion of patients cannot receive it despite meeting disease‐related criteria. In this review, “unsuitable”
Santino Caserta +12 more
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Regulated Cell Death in Idiopathic Pulmonary Fibrosis
This graphical abstract illustrates regulated cell death (RCD) across key pulmonary cell types—including alveolar epithelial cells, fibroblasts, macrophages, and endothelial cells—modulated through a dynamic death modulation network within the IPF microenvironment.
Xiaoyue Pan +10 more
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Sensing and Filtering Environmental Fluctuations: The Case of Biomolecular Condensates in Plants
The diversity of plant condensates reflects constraints of sessile organisms to coordinate postembryonic development with environmental adaptation. This review examines how plants employ condensates to integrate temperature, light, redox, and nutrient signals.
Panagiotis N. Moschou, Dorothee Staiger
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Droplet‐based microfluidics enables precise, high‐throughput microscale reactions but continues to face challenges in scalability, reproducibility, and data complexity. This review examines how artificial intelligence enhances droplet generation, detection, sorting, and adaptive control and discusses emerging opportunities for clinical and industrial ...
Junyan Lai +10 more
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Material‐Based Intelligence: Autonomous Adaptation and Embodied Computation in Physical Substrates
This perspective formulates a unifying framework for Material‐Based Intelligence (MBI), defining the physical requirements for materials to achieve embodied action, active memory and embodied information processing through intrinsic nonequilibrium dynamics. The design of intelligent materials often draws parallels with the complex adaptive behaviors of
Vladimir A. Baulin +4 more
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Molecular Probes for Tracking Reactive Oxygen Species at the Organelle Interface
This perspective charts the frontier of visualizing compartmentalized redox signaling across mitochondria, the ER, lysosomes, and the underexplored peroxisome. It discusses evolving molecular probe designs, the integration of multiplexed imaging, and the specific engineering challenges for tracking ROS at organelle interfaces.
Daniela Ceballos‐Ávila +1 more
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Central Dogma Cycle and Network: A Model for Cell Memory
This paper revisits the Central Dogma, expanding it to the Central Dogma cycle (CDC) and Central Dogma cyclic network (CDCN). These models frame cellular memory as a system of logic‐based processes with an architecture of interconnected cycles that more accurately describe cellular information flow in cells. ABSTRACT This paper proposes an extension of
Martin R. Schiller
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