Results 111 to 120 of about 29,739 (230)

Diagnostic antibodies at an inflection point: From discovery platforms to design‐oriented engineering

VIEW, EarlyView.
This study systematically organizes the evolution of diagnostic antibodies from discovery platforms to design‐oriented engineering and analyzes the strengths and limitations of each approach. Meanwhile, it provides a critical, literature‐driven synthesis of current challenges, proposing integrated strategies for assay‐aware and function‐driven antibody
Qitao Song, Lulai Xu, Weilin Wu, Fei Xie, Yantong Pan, Tiantian Yang, Xiaoxia Xu, Yanyin Lin, Lihua Zhang, Jiahui Zhou, Junyou Zhou, Linping Li, Zhanhui Wang, Weijing Yi, Jing Wang   +14 more
wiley   +1 more source

Ions as Architects of DNA Nanostructures: Mechanisms, Simulations, and Technological Frontiers

Small Structures
DNA, the most iconic molecular architecture, is not only the carrier of genetic information but also a programmable, biocompatible scaffold for nanoscale design.
Sergiy Perepelytsya, Dmytro Piatnytskyi, Tetiana Bubon, Narcis Cibotariu, Aatto Laaksonen, Francesca Mocci   +5 more
doaj   +1 more source

The Coloniality of Data: Police Databases and the Rationalization of Surveillance from Colonial Vietnam to the Modern Carceral State

The British Journal of Sociology, EarlyView.
ABSTRACT Tracing the early adoption of computer gang databases by the Los Angeles County Sheriff's Department and the Los Angeles Police Department in the 1980s to the deployment of computationally‐assisted surveillance during the Vietnam War, this paper uses a genealogical approach to compare surveillance technologies developed across the arc of ...
Christina Hughes
wiley   +1 more source

SemiSynBio: A new era for neuromorphic computing

Synthetic and Systems Biotechnology
Neuromorphic computing has the potential to achieve the requirements of the next-generation artificial intelligence (AI) systems, due to its advantages of adaptive learning and parallel computing. Meanwhile, biocomputing has seen ongoing development with
Ruicun Liu, Tuoyu Liu, Wuge Liu, Boyu Luo, Yuchen Li, Xinyue Fan, Xianchao Zhang, Wei Cui, Yue Teng   +8 more
doaj   +1 more source

How Fragmented Are Global Policy Debates on Health Data Sharing? Studying Fragmentation Through Discourse Network Analysis

JCMS: Journal of Common Market Studies, EarlyView.
Abstract Global policy‐making is often described as taking place in a fragmented and complex institutional landscape. In this article, we revisit the verdict of fragmentation through the lens of discourse network analysis, seeking to understand the extent to which global policy debates can be characterised as fragmented.
Maria Weickardt Soares, Anna Holzscheiter   +1 more
wiley   +1 more source

Whose knowledge, whose cure? traditional medicine and the boundaries of WIPO's 2024 genetic resources treaty

The Journal of World Intellectual Property, EarlyView.
Abstract Traditional medicine—including complementary, integrative, Indigenous, and ancestral practices—remains a vital source of healthcare for billions worldwide, particularly in the Global South. Despite its widespread use and biomedical relevance, traditional medicinal knowledge has long been excluded from dominant intellectual property systems ...
Tolulope Anthony Adekola
wiley   +1 more source

Matrix-Chain Multiplication Based on Combinatorial Allosteric DNA Strand Displacement

IEEE Access
DNA computing has gained widespread attention for leveraging the unique properties of DNA molecules to perform computational operations. As a fundamental tool for analyzing data and optimizing models, matrix operation plays an important role in intensive
Hengyan Guo, Mingliang Wang, Xuedong Zheng   +2 more
doaj   +1 more source

DNAwhisper: An Integrated Deep Learning Pyramidal Framework for Multi‐Trait Genomic Prediction and Adaptive Marker Prioritisation

Plant Biotechnology Journal, EarlyView.
ABSTRACT Genomic selection (GS) is critical for accelerating genetic gain in modern plant breeding. Deep learning approaches offer powerful non‐linear representation capabilities for modelling non‐additive effects. However, their application in GS remains restricted, as high‐dimensional, low‐sample and noisy data hinder the identification of ...
Yuexin Ma, Xiang Li, Xiaohao Ji, Chunying Wang, Di Zhang, Tingting Zhai, Haibo Wang, Ping Liu   +7 more
wiley   +1 more source

Circular single-stranded DNA as a programmable vector for gene regulation in cell-free protein expression systems

Nature Communications
Cell-free protein expression (CFE) systems have emerged as a critical platform for synthetic biology research. The vectors for protein expression in CFE systems mainly rely on double-stranded DNA and single-stranded RNA for transcription and translation ...
Zhijin Tian, Dandan Shao, Linlin Tang, Zhen Li, Qian Chen, Yongxiu Song, Tao Li, Friedrich C. Simmel, Jie Song   +8 more
doaj   +1 more source

Transcriptional Regulation of the Novel Theacrine Synthase Gene CsTcS2 by the CsTINY–CsWRKY33 Module Underpins Theacrine Biosynthesis in Camellia sinensis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Theacrine (1,3,7,9‐tetramethyluric acid) is a purine alkaloid detected in multiple wild and specialised tea germplasms (Camellia sinensis) from South China, including Kucha. However, the molecular mechanisms governing its biosynthesis remain poorly understood. Here, we identify CsTcS2 as a novel theacrine synthase in tea plant.
Ting Wu, Lihua Zhu, Chenyu Shao, Siyi Xie, Na Li, Xinyu Li, Fang Wang, Lvwen Peng, Huiying Jin, Fanghuizi Shang, Jianan Huang, Zhonghua Liu, Na Tian, Shuoqian Liu   +13 more
wiley   +1 more source