Results 131 to 140 of about 29,739 (230)
A New Conditional Transcription Factor for Use in Toxoplasma Gondii
Biotechnology Journal, Volume 21, Issue 5, May 2026.Graphical Abstract and Lay Summary A new conditional transcription factor (CTF) for Toxoplasma gondii reversibly regulates a reporter gene, achieving an outstanding signal‐to‐noise ratio. Gene expression is robust in the absence and nearly abolished in the presence of rapamycin, and the tool's modular design will facilitate application to varied genes ...
Mohammad Farouq Sharifpour +12 more
wiley +1 more source
Food and Energy Security, Volume 15, Issue 3, May/June 2026.ABSTRACT By 2050, the global population is projected to reach ~10 billion, leading to 50% increase in food demand. This growth will place immense pressure on agricultural systems that are already struggling with the impacts of climate change and resource depletion.
Chaquayla Katam +3 more
wiley +1 more source
Divide and control: split design of multi-input DNA logic gates. [PDF]
Chem Commun (Camb), 2015 Gerasimova YV, Kolpashchikov DM.
europepmc +1 more source
In vivo CAR therapies: Turning the patient into their own CAR factory
HemaSphere, Volume 10, Issue 5, May 2026.Abstract Over the past decade, ex vivo autologous chimeric antigen receptor (CAR)‐T‐cell therapies have reshaped the treatment of B‐cell malignancies. Despite their remarkable clinical efficacy, their application remains limited by complex manufacturing processes, demanding logistics, long turnaround times, and substantial costs. In vivo CAR approaches
François Vilcot +3 more
wiley +1 more source
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
MedComm, Volume 7, Issue 5, May 2026.The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
Small Science, Volume 6, Issue 5, May 2026.Aptamer‐functionalized nanocarriers represent a versatile platform for targeted therapy in bone and joint diseases. This review presents five complementary design strategies: free aptamers for soluble targets, bispecific multivalent constructs for enhanced avidity, nanoparticle‐conjugated aptamers for selective tissue accumulation, aptamer‐based ...
Hamdi Al‐Azzani +5 more
wiley +1 more source
CD24 in Melanoma: Biomarker, Innate Immune Checkpoint and Emerging Therapeutic Target
Experimental Dermatology, Volume 35, Issue 5, May 2026.ABSTRACT Immune checkpoint inhibitors have transformed the treatment of advanced melanoma, yet many patients develop primary or acquired resistance. Although most work has focused on adaptive checkpoints (PD‐1 and CTLA‐4), accumulating evidence implicates innate immune suppression and stem‐like, drug‐resistant melanoma cell states.
Claudia Lasalle +6 more
wiley +1 more source
New Phytologist, Volume 250, Issue 4, Page 2007-2025, May 2026.Summary In plants, multiple cell types contribute to immunity, but what division of labor exists among cell types when immunity is activated? We compared, at single‐cell resolution, the response of Arabidopsis thaliana leaf cells during pattern‐triggered and effector‐triggered immunity (PTI/ETI), sampled at 3 and 5 h after infection with Pseudomonas ...
Shanshan Wang +5 more
wiley +1 more source
p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Intraarticular injection of lentiviral p21 shRNA (targeting Cdkn1a) into murine knees with full‐thickness cartilage defects reduces chondrocyte senescence while enhancing matrix repair with minimal hepatic off‐target effects. ABSTRACT Focal articular cartilage defects lack intrinsic regenerative capacity and can progress to osteoarthritis as no ...
Leila Larijani +4 more
wiley +1 more source