Results 51 to 60 of about 2,256,913 (199)

Self‐Assembling Molecular Logic Gates Based on DNA Crossover Tiles

, 2017
DNA-based computational hardware has attracted ever-growing attention due to its potential to be useful in the analysis of complex mixtures of biological markers.
Dmitry M. Kolpashchikov, Eleanor A. Campbell, Evan Peterson, Kolpashchikov, Dmitry M., Campbell, Eleanor A., Peterson, Evan   +5 more
core   +1 more source

EDNRA Forms a Positive Feedback Loop with the Hippo/YAP Axis to Drive Triple‐Negative Breast Cancer Progression

Advanced Science, EarlyView.
Endothelin receptor type A (EDNRA) and the Hippo/YAP pathway form a self‐reinforcing loop that sustains triple‐negative breast cancer. EDNRA activates YAP through Gαq/11–Rho/ROCK–LATS signaling, while YAP/TEAD4 reciprocally drives EDNRA transcription.
Zehao Hong, Boyang Li, Jiahui Xu, Ruonan Lin, Jinghao Pan, Chenlu Fang, Boxiang Zhang, Lucy Yue Lau, Richard J. Aldridge, Elizabeth A. Whitmore, Yi Chen   +10 more
wiley   +1 more source

Leakage Power Analysis and Comparison of Deep Submicron Logic Gates

, 2004
Basic combinational gates, including NAND, NOR and XOR, are fundamental building blocks in CMOS digital circuits. This paper analyses and compares the power consumption due to transistor leakage of low-order and high-order basic logic gates. The NAND and
Merrett, Geoff, Geoff Merrett, Bashir M. Al-Hashimi, Al-Hashimi, Bashir M.   +3 more
core   +2 more sources

Effect of Variability in SWCNT-Based Logic Gates

, 2009
This work is concerned with Carbon Nanotube diameter variations and the resulting uncertainties on the behavior of logic gates made from Single Walled Carbon Nanotubes (SWCNTs).
Ahmadi, Arash, Maharatna, Koushik, Shahidipour, Hamed   +2 more
core   +1 more source

Continuous Evolution System Based on Toxin–Antitoxin System Combined with Base Deaminase Accelerates the In Vivo Modification of Target Proteins

Advanced Science, EarlyView.
The promoted Escherichia coli‐assisted continuous evolution (PEACE) system operates through a stringent three step genetic circuit: target gene mutation via a deaminase–T7 RNA polymerase (T7 RNAP) fusion, coupling variant function to antitoxin expression, and growth based selection of surviving cells.
Xinyu Zhang, Zhanzhi Liu, Ying Xu, Mingjing Sun, Guangzhen Zhou, Deming Rao, Xiaoqian Chen, Sheng Wang, Zhigang Li, Yan Huang, Jing Wu   +10 more
wiley   +1 more source

A multi-commodity network model for optimal quantum reversible circuit synthesis.

PLoS ONE, 2021
Quantum computing is a newly emerging computing environment that has recently attracted intense research interest in improving the output fidelity, fully utilizing its high computing power from both hardware and software perspectives.
Jihye Jung, In-Chan Choi
doaj   +1 more source

Molecular Logic Gates on DNA Origami Nanostructures for MicroRNA Diagnostics

, 2016
Molecular computing holds great promise for diagnosis and treatment of diseases at the molecular level; nevertheless, designing molecular logic gates to operate programmably and autonomously for molecular diagnostics still remains challenging.
Yi Zhang (9093), Bin Dai (320307), Dannong He (386180), Bin Zhao (276445), Chunhai Fan (9209), Huajie Liu (1844284), Dongfang Wang (678031), Shiping Song (9206), Yanming Fu (1844281), Juan Yan (746051), Jie Chao (582561)   +10 more
core   +1 more source

Mepce Restrains Ferroptosis in Prostate Cancer Through 7SK–P‐TEFb Pause Control

Advanced Science, EarlyView.
Genome‐wide CRISPR screening identifies MEPCE as a pause‐control regulator that restrains ferroptosis in prostate cancer. MEPCE loss releases P‐TEFb/CDK9 from 7SK snRNP control, enhances RNAPII Ser2 phosphorylation, and accelerates NRF2‐HMOX1‐driven labile iron accumulation and lipid peroxidation, revealing a transcriptional kinetic gate that lowers ...
Tongtong Zhang, Xiangyang Zhan, Jiexiang Zhang, Mingyue Tan, Chuanmin Chu, Guanqun Ju, Xinyu Zhai, Jianyi Gu, Huirong Zhu, Dongliang Xu   +9 more
wiley   +1 more source

Singleton {NOT} and Doubleton {YES; NOT} Gates Act as Functionally Complete Sets in DNA-Integrated Computational Circuits

Nanomaterials
A functionally complete Boolean operator is sufficient for computational circuits of arbitrary complexity. We connected YES (buffer) with NOT (inverter) and two NOT four-way junction (4J) DNA gates to obtain IMPLY and NAND Boolean functions, respectively,
Andrea C. Bardales, Quynh Vo, Dmitry M. Kolpashchikov   +2 more
doaj   +1 more source

Fluorogenic RNA Aptamers: A Nano-platform for Fabrication of Simple and Combinatorial Logic Gates

Nanomaterials, 2018
RNA aptamers that bind non-fluorescent dyes and activate their fluorescence are highly sensitive, nonperturbing, and convenient probes in the field of synthetic biology.
Victoria Goldsworthy, Geneva LaForce, Seth Abels, Emil F. Khisamutdinov   +3 more
doaj   +1 more source