Results 71 to 80 of about 2,256,913 (199)
Profiling the miRNAs for Early Cancer Detection using DNA-based Logic Gates [PDF]
Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017 Background: DNA-based computing is an emerging research aspect that enables the in-vivo computation and decision making with significant correctness.
Tahereh Yahya +2 more
doaj
Advanced Science, EarlyView.An integrative review of microfluidics‐enabled wearables and implantable systems reveals a single‐track translation pipeline, bridging functional biomaterials with clinical utility. Dynamic feedback loops driven by artificial intelligence advance diagnostics toward personalized closed‐loop theranostics.
Ke Huang +3 more
wiley +1 more source
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
A Cascaded DNA Nanocircuit for Multi‐Signal‐Responsive Precision siRNA Delivery in Cancer Therapy
Advanced Science, EarlyView.A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Yan Zhao +14 more
wiley +1 more source
2013 Annual Letter from Bill Gates [PDF]
, 2013 In previous annual letters, Gates focused on the power of innovation to reduce hunger, poverty, and disease. But any innovation -- whether it's a new vaccine or an improved seed -- can't have an impact unless it reaches the people who will benefit from ...
Bill Gates
core +2 more sources
From Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits
Advanced Science, EarlyView.This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...
Jinduo Zhang +5 more
wiley +1 more source
Advanced Science, EarlyView.A tumor‐state‐gated metallo‐DNAzyme framework integrates miR‐21/APE1‐responsive GLUT1 silencing with Ca/Cu‐partitioned metal–nucleic acid assembly and cystine loading. The framework first weakens glucose‐dependent metabolic buffering and then amplifies copper‐ and disulfide‐associated stress, converting tumor metabolic adaptation into programmable ...
Xiaodong Ma +8 more
wiley +1 more source
Gates Notice of Adopted Amendment (2009-08-05)
, 2009 6 pp. Adopted 2009-08-05. Department of Land Conservation and Development Notice of Adopted AmendmentThe City of Gates amended portion of its comprehensive plan sections of which had not be updated since 1978.
Gates
core +1 more source
Erasable and Field Programmable DNA Circuits Based on Configurable Logic Blocks
Advanced ScienceDNA is commonly employed as a substrate for the building of artificial logic networks due to its excellent biocompatibility and programmability. Till now, DNA logic circuits are rapidly evolving to accomplish advanced operations.
Yizhou Liu +11 more
doaj +1 more source
Advanced Science, EarlyView.CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley +1 more source