Results 61 to 70 of about 29,739 (230)

CRISPR Interference Modules as Low-Burden Logic Inverters in Synthetic Circuits

Frontiers in Bioengineering and Biotechnology, 2022
CRISPR and CRISPRi systems have revolutionized our biological engineering capabilities by enabling the editing and regulation of virtually any gene, via customization of single guide RNA (sgRNA) sequences.
Massimo Bellato, Massimo Bellato, Massimo Bellato, Angelica Frusteri Chiacchiera, Angelica Frusteri Chiacchiera, Elia Salibi, Elia Salibi, Michela Casanova, Michela Casanova, Davide De Marchi, Davide De Marchi, Ignazio Castagliuolo, Maria Gabriella Cusella De Angelis, Maria Gabriella Cusella De Angelis, Paolo Magni, Paolo Magni, Lorenzo Pasotti, Lorenzo Pasotti   +17 more
doaj   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Evolving Gene Regulatory Networks with Mobile DNA Mechanisms

, 2013
This paper uses a recently presented abstract, tuneable Boolean regulatory network model extended to consider aspects of mobile DNA, such as transposons.
Adamatzky, Andrew, Bull, Larry
core   +1 more source

RATEX: A Scalable RNA‐Based Platform for Logical and Multi‐Layered Cellular Programming

Angewandte Chemie, EarlyView.
RATEX integrated ribosome‐mediated transcription control with synthetic RNA regulators, enabling simultaneous processing of RNA, metabolite, and small‐molecule inputs through complex logic operations within a single transcript. The platform achieves up to 1,492‐fold gene regulation, multi‐input hybrid logic gates, RNA‐programmed signaling cascades, and
Hyunseop Goh, Hansol Kang, Chaeri Kim, Jongmin Kim   +3 more
wiley   +2 more sources

Implementation of 1-and 2-input logic gates and composite circuits via 3-input 1-output DNA algorithmic assembly

Nano Express
We describe the assembly of 3-input 1-output DNA algorithmic logic gates capable of generating algorithmic lattices through tile-based self-assembly.
Thi Bich Ngoc Nguyen, Sungjin Lee, Anshula Tandon, Thi Hong Nhung Vu, Yeonju Nam, Sung Ha Park   +5 more
doaj   +1 more source

Synthetic RNA-based logic computation in mammalian cells

Nature Communications, 2018
The construction of complex RNA-delivered genetic circuits in mammalian cells is challenging, though offers advantages over DNA circuits in clinical use.
Satoshi Matsuura, Hiroki Ono, Shunsuke Kawasaki, Yi Kuang, Yoshihiko Fujita, Hirohide Saito   +5 more
doaj   +1 more source

Constructing Controllable Logic Circuits Based on DNAzyme Activity

Molecules, 2019
Recently, DNA molecules have been widely used to construct advanced logic devices due to their unique properties, such as a simple structure and predictable behavior.
Fengjie Yang, Yuan Liu, Bin Wang, Changjun Zhou, Qiang Zhang   +4 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Bottom‐Up Coacervate‐Based Artificial Cells: Integrating Cellular Hallmarks into Complex Life‐Like Systems

Angewandte Chemie, EarlyView.
Current interest in artificial cell research underscores its potential to deepen our understanding of life's fundamental processes. This review highlights advances in bottom‐up coacervate‐based artificial cell engineering via combined integration of cellular hallmarks.
Arjan Hazegh Nikroo, Angshuman Das, Madelief A. M. Verwiel, Jan C. M. van Hest   +3 more
wiley   +2 more sources

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source