Results 131 to 140 of about 2,686,549 (398)
BMC Genomics, 2017 Background DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected.
Ali Sharifi-Zarchi +10 more
doaj +1 more source
Comparative analysis of genome-wide DNA methylation in Neurospora
Epigenetics, 2020 DNA methylation is an epigenetic mark that plays an important role in genetic regulation in eukaryotes. Major progress has been made in dissecting the molecular pathways that regulate DNA methylation.
Sara Hosseini +4 more
doaj +1 more source
Acta Neuropathologica, 2018 Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation patterns [6].
D. Capper +26 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
DNMT inhibitors reverse a specific signature of aberrant promoter DNA methylation and associated gene silencing in AML [PDF]
, 2014 <b>Background</b>. Myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are neoplastic disorders of hematopoietic stem cells. DNA methyltransferase inhibitors (DNMTi), 5-azacytidine (AzaC) and 5-aza-2’-deoxycytidine (Decitabine),
Adams, Peter +8 more
core +2 more sources
Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome
Nutrients, 2019 DNA methylation is an epigenetic mechanism that is essential for regulating gene transcription. However, aberrant DNA methylation, which is a nearly universal finding in cancer, can result in disturbed gene expression.
Abeer M. Mahmoud, Mohamed M. Ali
semanticscholar +1 more source
Possible role of human ribonuclease dicer in the regulation of R loops
FEBS Open Bio, EarlyView.R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik +2 more
wiley +1 more source
BMC Genomics, 2010 Background DNA methylation is an epigenetic mechanism with important regulatory functions in animals. While the mechanism itself is evolutionarily ancient, the distribution and function of DNA methylation is diverse both within and among phylogenetic ...
Gavery Mackenzie R, Roberts Steven B
doaj +1 more source
DNA methylation and socioeconomic status in a Mexican-American birth cohort. [PDF]
, 2018 Background: Maternal social environmental stressors during pregnancy are associated with adverse birth and child developmental outcomes, and epigenetics has been proposed as a possible mechanism for such relationships.
Coker, Eric +4 more
core +1 more source
The DNA methylation landscape in cancer
Essays in Biochemistry, 2019 As one of the most abundant and well-studied epigenetic modifications, DNA methylation plays an essential role in normal development and cellular biology.
Ksenia Skvortsova +2 more
semanticscholar +1 more source