Results 141 to 150 of about 2,729,754 (384)
Identification of DNA methylation prognostic signature of acute myelocytic leukemia.
PLoS ONE, 2018 BackgroundThe aim of this study is to find the potential survival related DNA methylation signature capable of predicting survival time for acute myelocytic leukemia (AML) patients.MethodsDNA methylation data were downloaded.
Haiguo Zhang +6 more
doaj +1 more source
Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome
Nutrients, 2019 DNA methylation is an epigenetic mechanism that is essential for regulating gene transcription. However, aberrant DNA methylation, which is a nearly universal finding in cancer, can result in disturbed gene expression.
Abeer M. Mahmoud, Mohamed M. Ali
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli +4 more
wiley +1 more source
SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions
Nucleic Acids Research, 2018 We report a new class of artifacts in DNA methylation measurements from Illumina HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed hybridization to target DNA, often due to germline or somatic deletions and manifest as ...
Wanding Zhou +3 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti +8 more
wiley +1 more source
Epigenetics & Chromatin, 2019 Data mining of The Cancer Genome Atlas (TCGA) data has significantly facilitated cancer genome research and provided unprecedented opportunities for cancer researchers.
Yin Li, D. Ge, Chunlai Lu
semanticscholar +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Sensitivity of transcription factors to DNA methylation
Essays in Biochemistry, 2019 Dynamic binding of transcription factors (TFs) to regulatory elements controls transcriptional states throughout organism development. Epigenetics modifications, such as DNA methylation mostly within cytosine-guanine dinucleotides (CpGs), have the ...
Éléa Héberlé, A. Bardet
semanticscholar +1 more source
Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium
FEBS Open Bio, EarlyView.By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita +3 more
wiley +1 more source
Genome Biology, 2018 Background DNA methylation is influenced by both environmental and genetic factors and is increasingly thought to affect variation in complex traits and diseases.
Lucas T. Husquin +10 more
doaj +1 more source