Results 141 to 150 of about 551,287 (374)
DNA methylation at a CCGG sequence in the large intron of the rabbit β-globin gene: tissue-specific variations [PDF]
, 1978 Cees Waalwijk, Richard A. Flavell
openalex +1 more source
Molecular Analysis of N6-Methyladenine Patterns in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e Nuclear DNA [PDF]
, 1989 We have cloned two DNA fragments containing 5\u27-GATC-3\u27 sites at which the adenine is methylated in the macronucleus of the ciliate Tetrahymena thermophila. Using these cloned fragments as molecular probes, we analyzed the maintenance of methylation
Capowski, Elizabeth E. +3 more
core +1 more source
Advanced Engineering Materials, EarlyView.Molecular dynamics simulations are advancing the study of ribonucleic acid (RNA) and RNA‐conjugated molecules. These developments include improvements in force fields, long‐timescale dynamics, and coarse‐grained models, addressing limitations and refining methods.
Kanchan Yadav, Iksoo Jang, Jong Bum Lee
wiley +1 more source
Genome Biology, 2018 Background DNA methylation is influenced by both environmental and genetic factors and is increasingly thought to affect variation in complex traits and diseases.
Lucas T. Husquin +10 more
doaj +1 more source
Repair methylation of parental DNA In synchronized cultures of Novikoff hepatoma cells [PDF]
, 1975 Julia K. Hilliard, Thomas W. Sneider
openalex +1 more source
Advanced Healthcare Materials, EarlyView.The challenges of studying inflammatory bowel disease (IBD), highlighting limitations of traditional 2D cell cultures and animal models are discussed here. It introduces human intestine organ‐on‐chip (OoC) models as a promising alternative, capable of more accurately mimicking the intestinal microenvironment.
Tim Kaden +5 more
wiley +1 more source
Epigenetics & Chromatin, 2018 Background DNA shape analysis has demonstrated the potential to reveal structure-based mechanisms of protein–DNA binding. However, information about the influence of chemical modification of DNA is limited.
Satyanarayan Rao +5 more
doaj +1 more source
Transform-Domain Classification of Human Cells based on DNA Methylation Datasets [PDF]
arXiv, 2019 A novel method to classify human cells is presented in this work based on the transform-domain method on DNA methylation data. DNA methylation profile variations are observed in human cells with the progression of disease stages, and the proposal is based on this DNA methylation variation to classify normal and disease cells including cancer cells. The
arxiv
DNA Synthesis, Methylation and Degradation During Conjugation in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]
, 1985 We have investigated the timing of DNA synthesis, methylation and degradation during macronuclear development in the ciliate, Tetrahymena thermophila. DNA synthesis was first detected in the anlagen early in macronuclear development, but the majority of ...
Harrison, Gail Singer +1 more
core +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
Advanced Healthcare Materials, EarlyView.The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq +4 more
wiley +1 more source