Results 161 to 170 of about 382,011 (287)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Genome-wide DNA methylation analysis in precursor B-cells

, 2014
Md Almamun, Benjamin T Levinson, Susan T. Gater, Robert D. Schnabel, Gerald L. Arthur, J. Wade Davis, Kristen H. Taylor   +6 more
openalex   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

wgbstools: a computational suite for DNA methylation sequencing data analysis. [PDF]

Life Sci Alliance
Loyfer N, Rosenski J, Kaplan T.
europepmc   +1 more source

Additional file 9: of Sex influences DNA methylation and gene expression in human skeletal muscle myoblasts and myotubes

, 2019
Cajsa DavegĂĽrdh, Elin Hall, Christa Broholm, Tora Henriksen, M. Hauge, Bente Klarlund Pedersen, Camilla Schéele, Charlotte Ling   +7 more
openalex   +1 more source

Supplementary Figures 1-5 from Genome-wide DNA Methylation Events in <i>TMPRSS2–ERG</i> Fusion-Negative Prostate Cancers Implicate an EZH2-Dependent Mechanism with <i>miR-26a</i> Hypermethylation

, 2023
Stefan T. Börno, Axel Fischer, Martin Kerick, Maria Fälth, Mark Laible, Jan C. Brase, Ruprecht Kuner, Andreas Dahl, Christina Grimm, Behnam Sayanjali, Melanie Isau, Christina Röhr, Andrea Wunderlich, Bernd Timmermann, Rainer Claus, Christoph Plass, Markus Graefen, Ronald Simon, Francesca Demichelis, Mark A. Rubin, Guido Sauter, Thorsten Schlomm, Holger Sültmann, Hans Lehrach, Michal R. Schweiger   +24 more
openalex   +1 more source

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment. [PDF]

Aging Cell
Kasamoto J, González J, Markov Y, Sehgal R, Lee E, Dwaraka VB, Smith R, Higgins-Chen AT.   +7 more
europepmc   +1 more source

Imputed DNA methylation outperforms measured loci associations with smoking and chronological age

Anne Richmond, Jure Mur, Sarah E. Harris, Janie Corley, Hannah R. Elliott, Christopher N. Foley, Eilís Hannon, Zhana Kuncheva, Josine L. Min, Mahdi Moqri, Magatte Ndiaye, Benjamin B. Sun, Catalina A. Vallejos, Kejun Ying, Vadim N. Gladyshev, Simon R. Cox, Daniel L. McCartney, Riccardo E. Marioni   +17 more
openalex   +1 more source

Deep enzymology data related to Gao et al.: Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

, 2020
Albert Jeltsch, Pavel Bashtrykov, Max Emperle, Sabrina Adam, Michael Dukatz   +4 more
openalex   +1 more source