Results 231 to 240 of about 2,768,548 (336)

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

Oxidative stress - Alzheimer's disease - DNA methylation: the role of arsenic. [PDF]

Essays Biochem
Antinori D, Lucarelli M, Fuso A.
europepmc   +1 more source

DNA Methylation Changes and Phenotypic Adaptations Induced Repeated Extreme Altitude Exposure at 8848 Meters [PDF]

Shixuan Zhang, La Yang, Zhuoma Duoji, Danzeng Qiangba, Xiaoxi Hu, Zeyu Jiang, Dandan Hou, Zixin Hu, Zhuoma Basang   +8 more
openalex   +1 more source

DNA methylation of germ-cell-specific basic helix-loop-helix (HLH) transcription factors, Sohlh2 and Figl  during gametogenesis [PDF]

, 2011
Bo Pan, H. Chao, Bo Chen, Ping Zhang, Lan Li, Xiao-Feng Sun, Wei Shen   +6 more
openalex   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Association of blood-based DNA methylation of lncRNAs with Alzheimer's disease diagnosis. [PDF]

Clin Epigenetics
Tian G, Zheng D, Zhang N, Deng W, Xu J, Huang C, Chen Q, Hu S, Xin L, Wang H, Wang B, Li K, Xu D.   +12 more
europepmc   +1 more source

Structural Variation and 3D Genome‐Driven DNA/RNA Methylation Divergence Contributing to Cotton Fiber Domestication

Advanced Science, EarlyView.
These findings elucidated the crucial role of the “SVs‐3D genome remodeling‐epigenetic modifications‐gene expression” cascade regulatory network in cotton fiber domestication, offering both a theoretical foundation and genetic resources for molecular design breeding in fiber crops.
Lei Shao, Shangkun Jin, Haojie Jiang, Tianyu Pan, Zesheng Rui, Xiaowen Shi, Ting Zhao, Zhanfeng Si, Xueying Guan, Yan Hu, Tianzhen Zhang, Lei Fang   +11 more
wiley   +1 more source

DNA methylation data from Japanese patients with Rubinstein-Taybi syndrome. [PDF]

Hum Genome Var
Kawai T, Aoki T, Nakabayashi K, Hata K, Kaname T, Kosaki R.   +5 more
europepmc   +1 more source

A Trypsin‐Like Serine Protease ZmNAL1a Fine‐Tunes Maize Floral Transition and Flowering Time

Advanced Science, EarlyView.
This study identifies a trypsin‐like serine protease, ZmNAL1a, that moves from leaves to the shoot apical meristem. ZmNAL1a promotes the floral transition by degrading TOPLESS‐like corepressor REL2, which thereby enhances the expression of key flowering genes through elevating histone acetylation and relieving REL2–ZmEREBP147‐mediated transcriptional ...
Nan Li, Qiang Ning, Zhen Li, Qian Zhang, Peilu Zhu, Jimin Zhan, Yunfu Li, Zhen Li, Liang Dong, Qing Xiong, Jiahao Liao, Jie Liu, David Jackson, Munenori Kitagawa, Zuxin Zhang, Lei Liu   +15 more
wiley   +1 more source

Maternal smoking during pregnancy is associated with DNA methylation in early adolescence: A sibling comparison design.

Nikolina Nonkovic, Kristine Marceau, John E. McGeary, Amanda M. Ramos, Rohan H. C. Palmer, Andrew C. Heath, Valerie S Knopik   +6 more
openalex   +1 more source