Results 271 to 280 of about 2,768,548 (336)

NUDT21‐mediated Alternative Polyadenylation of CDK19 Reprograms Cholesterol Biosynthesis to Drive Colorectal Cancer Progression

Advanced Science, EarlyView.
NUDT21 is overexpressed in colorectal cancer tumors and promotes colorectal cancer progression. NUDT21 promotes the production of a cyclin‐dependent kinase 19 (CDK19) mRNA isoform with a long 3′ UTR, which enhances cytoplasmic export and translation. Truncation of the CDK19 long 3′ UTR phenocopies NUDT21 loss, recapitulating the defects in cholesterol ...
Yeping Yu, Jixin Ma, Minwei Zhou, Xiaodong Gu, Yiming Zhou, Zhenyang Li, Tianyu Zhang, Wei Gong, Chuanxin Huang, Jianbin Xiang   +9 more
wiley   +1 more source

Salivary DNA methylation and pubertal development in adolescents. [PDF]

Sci Rep
deSteiguer AJ, Smith T, Goode JA, Willems YE, Schowe AM, Czamara D, Mönkediek B, Pahnke CKL, Forstner AJ, Binder EB, Schneper L, Notterman DA, Tucker-Drob EM, Raffington L, Mitchell C, Harden KP.   +15 more
europepmc   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

Trans-Tissue Effects of Hippocampus- and Blood-Derived DNA Methylation Risk Scores on Bipolar Disorder Diagnosis. [PDF]

Bipolar Disord
Ohi K, Fujikane D, Takai K, Kuramitsu A, Muto Y, Sugiyama S, Shioiri T.   +6 more
europepmc   +1 more source

Genome-scale DNA methylation maps of pluripotent and differentiated cells

Nature, 2008
A. Meissner, T. Mikkelsen, H. Gu, Marius Wernig, J. Hanna, A. Sivachenko, Xiaolan Zhang, B. Bernstein, C. Nusbaum, D. Jaffe, A. Gnirke, R. Jaenisch, E. Lander   +12 more
semanticscholar   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Library Preparation for Genome-Wide DNA Methylation Profiling. [PDF]

Bio Protoc
Hsu FM, Pellegrini M, Chen PY.
europepmc   +1 more source

Ras GTPase-Activating Protein-Binding Protein 1 Affected the Proliferation, Apoptosis, and Oxidative Stress Damage of Gastric Cancer Cells by Regulating the Methylation Level of the Vezatin DNA

Yuqi Wang, Ruzhen Jia, Lei Shi, Junmei Jiang, Jian Ge   +4 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Reviewer #2 (Public review): DNA methylation insulates genic regions from CTCF loops near nuclear speckles

openalex   +1 more source