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DNA methylation, mitochondria, and programmed aging
Biochemistry (Moscow), 2015DNA methylation is a key epigenetic process involved in the regulation of nuclear gene expression. Progress in the study of genomic DNA methylation led to the precise identification of methylation sites reflecting biological age of cells and tissues. However, the functional significance of mitochondrial DNA (mtDNA) methylation remains unknown.
L A, Zinovkina, R A, Zinovkin
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DNA methylation in aging of mice
Mechanisms of Ageing and Development, 1987Methylation of cytidine residues of DNA appears to be involved in the control of gene expression; therefore, hypomethylation of the DNA can be considered to be an active rather than a passive process. Previous studies of mammalian DNA methylation during aging have produced an assortment of results. In this study, we have examined the change in DNA base
R P, Singhal +2 more
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DNA Methylation in Cancer and Aging
Cancer Research, 2016Abstract DNA methylation is known to be abnormal in all forms of cancer, but it is not really understood how this occurs and what is its role in tumorigenesis. In this review, we take a wide view of this problem by analyzing the strategies involved in setting up normal DNA methylation patterns and understanding how this stable epigenetic
Michael, Klutstein +3 more
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DNA methylation in cancer and ageing
Mechanisms of Ageing and Development, 2002Epigenetic gene silencing through DNA methylation is now clearly thought to be one of the important steps in the mechanism underlying tumourigenesis. The methylation of several genes increases with age in normal tissues such as the colon. Methylation related to cancer and ageing may lead to new biomarkers and therapeutic concepts for cancer.
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Impact of aging on DNA methylation
Ageing Research Reviews, 2003The biochemistry of aging is complex, with biologically significant changes occurring in proteins, lipids and nucleic acids. One of these changes is in the methylation of DNA. DNA methylation is a mechanism modifying gene expression. The methylation of sequences in or near regulatory elements can suppress gene expression through effects on DNA binding ...
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DNA Methylation in Aging and Cancer
Journal of Gerontology, 1989DNA methylation processes appear to be disturbed in senescing mice and also in some tumor cells. Although it is possible that age-related demethylation of DNA could predispose cells to carcinogenic transformation, present evidence does not favor this hypothesis.
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DNA methylation, ageing and ribosomal genes activity
Biogerontology, 2000DNA methylation is an epigenetic mechanism controlling of gene expression. We studied the effect of a demethylation agent 5-azacytidine, on ribosomal gene activity observed by Nucleolus Staining Giemsa in the chromosomes of eight Alzheimer's disease patients, eight elderly healthy individuals and eight young healthy controls.
Carvalho, Cristina Valletta de UNIFESP +2 more
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DNA methylation in cognition comes of age
Nature Neuroscience, 2012A study reveals that aged mice have decreased hippocampal expression of the DNA methyltransferase Dnmt3a2; re-expression in aged mice reverses memory deficits, and knockdown in young mice impairs memory formation.
Susan C, Su, Li-Huei, Tsai
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Age-related Macular Degeneration and DNA Methylation
Epigenomics, 2013239 ISSN 1750-1911 10.2217/EPI.13.19 © 2013 Future Medicine Ltd Epigenomics (2013) 5(3), 239–241 “The finding of epigenetic changes in age-related macular degeneration opens the door for the exploration of the role of environmental risk factors that may reduce or enhance the risk of age-related macular degeneration, allowing characterization of immune ...
Paul N, Baird, Lai, Wei
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Age-related DNA methylation changes for forensic age-prediction
International Journal of Legal Medicine, 2014There is no available method of age-prediction for biological samples. The accumulating evidences indicate that DNA methylation patterns change with age. Aging resembles a developmentally regulated process that is tightly controlled by specific epigenetic modifications and age-associated methylation changes exist in human genome.
Shao Hua, Yi +4 more
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