Results 141 to 150 of about 2,516,689 (307)

Methionine Synthase Interacts With the Methionine Adenosyl-Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus. [PDF]

J Inherit Metab Dis
Jeandel M, Alberto JM, Baspinar O, Robert A, Dreumont N, Alsahly Z, Meyre D, Guéant JL, Coelho D.   +8 more
europepmc   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source

Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation.

American Journal of Respiratory Cell and Molecular Biology, 2015
Benjamin D. Singer, J. Mock, N. Aggarwal, B. Garibaldi, V. Sidhaye, M. Florez, E. Chau, K. Gibbs, P. Mandke, A. Tripathi, S. Yegnasubramanian, L. King, F. D’Alessio   +12 more
semanticscholar   +1 more source

DNA methyltransferase inhibitors in oncology: clinical progress, limitations and future directions. [PDF]

Epigenomics
Michael DC, Mehdipour P.
europepmc   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Mechanisms of DNA methyltransferase 3A1-mediated DNA methylation of nucleosomes. [PDF]

J Biol Chem
Ward E, McDonald D, Holl T, Reich N.
europepmc   +1 more source

Long Noncoding RNAs in Aortic Dissection: Mechanistic Roles and Therapeutic Potential

AGING MEDICINE, EarlyView.
Aortic dissection (AD) involves vascular inflammation, VSMC dysfunction, and ECM degradation. LncRNAs regulate AD progression via ceRNA networks, with great potential as diagnostic biomarkers and therapeutic targets, while further clinical validation is needed.
Chao Chang, Yongrong Lan, Zhenhua Wu, Jie Geng, Zhigang Guo, Qingliang Chen   +5 more
wiley   +1 more source

A targeting sequence directs DNA methyltransferase to sites of DNA replication in mammalian nuclei.

Cell, 1992
H. Leonhardt, A. W. Page, H. Weier, T. Bestor   +3 more
semanticscholar   +1 more source

Epigenetic regulation in prokaryotes: transcriptional and phenotypic outcomes of DNA methyltransferase activity. [PDF]

FEMS Microbiol Rev
Sharaf S, Cappelletti M, Oggioni MR, Hijazi K.   +3 more
europepmc   +1 more source

DNA methyltransferase inhibitors in hematological malignancies and solid tumors. [PDF]

Int J Cancer
Wenger V, Garcia-Manero G, Zeiser R, Lübbert M.   +3 more
europepmc   +1 more source